Phenotypes Associated with This Genotype

Genotype
MGI:3834483

• Allelic Composition: Tg(Ly6a-TK,-BCR/ABL1)IS9AIsg/0
• Genetic Background: involves: C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:144382 )

• all mice die by 18 months of age

• only 23% of ganciclovir-treated mice die during treatment

neoplasm

increased chronic myelocytic leukemia incidence ( J:144382 )

• all mice develop chronic myeloid leukemia by 6 to 10 months of age with progression to blast crisis

• however, treatment with ganciclovir reduced the number of mice that develop tumors and cures chronic myeloid leukemia in sick mice

• however, Sca1+Lin- cells from ganciclovir-treated mice fail to cause leukemia when engrafted into an irradiated wild-type mouse

immune system

increased leukocyte cell number ( J:144382 )

• mice exhibit increased white blood cell count compared to in wild-type mice

• however, treatment with ganciclovir can restore white blood cell counts to normal

increased neutrophil cell number ( J:144382 )

hematopoietic system

increased leukocyte cell number ( J:144382 )

• mice exhibit increased white blood cell count compared to in wild-type mice

• however, treatment with ganciclovir can restore white blood cell counts to normal

increased neutrophil cell number ( J:144382 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic myeloid leukemia		DOID:8552	OMIM:608232	J:144382