Phenotypes Associated with This Genotype

Genotype
MGI:3834579

• Allelic Composition: Slitrk1^tm1Jaru/Slitrk1^tm1Jaru
• Genetic Background: B6.129P2-Slitrk1^tm1Jaru

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:145441 )

• fewer than expected homozygotes are found at weaning

• no further losses were detected during behavioral testing

postnatal lethality, incomplete penetrance ( J:145441 )

• fewer than expected homozygotes are found at weaning

growth/size/body

decreased body weight ( J:145441 )

• males weigh about 11% less than wild-type littermates

• no significant difference in weight is detected for females

behavior/neurological

decreased coping response ( J:145441 )

• spend more time floating immobile in a forced swim test and more time immobile in a tail suspension test

increased anxiety-related response ( J:145441 )

• mice spend less time in the open arms and have fewer entries into the open arms in an elevated plus maze

• treatment with clonidine attenuates the increase in anxiety related behaviors

increased fear-related response ( J:145441 )

• increase in freezing in response to the context alone in a fear conditioning test

decreased locomotor activity ( J:145441 )

• pronounced decrease in locomotor activity in a variety of assays

• activity in the home cage is reduced in the light phase but not in the dark phase

nervous system

nervous system phenotype ( J:145441 )

N • no anatomical or histological defects are detected in the brain

abnormal nervous system physiology ( J:145441 )

• norepinephrine levels are significantly increased in the prefrontal cortex

• 3-methoxy-4-hydroxyphenylglycol (MHPG, a metabolite of norepinephrine) levels are elevated in the nucleus accumbens

• choline and acteylcholine levels in the striatum are reduced

homeostasis/metabolism

abnormal noradrenaline level ( J:145441 )

• norepinephrine levels are significantly increased in the prefrontal cortex

• 3-methoxy-4-hydroxyphenylglycol (MHPG, a metabolite of norepinephrine) levels are elevated in the nucleus accumbens

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Gilles de la Tourette syndrome		DOID:11119	OMIM:137580	J:145441