Phenotypes Associated with This Genotype

Genotype
MGI:3834850

• Allelic Composition: Cp^tm1Yos/Cp^tm1Yos
• Genetic Background: C.129P2-Cp^tm1Yos

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal lipid homeostasis ( J:142713 )

• mice treated for 4 weeks with 10mg/kg-day of rotenone starting at 13 weeks

• elevated levels of the lipid peroxidation product acrolein in hippocampal neuron cytoplasm

• ubiquitin levels elevated as well

behavior/neurological

abnormal locomotor activation ( J:142713 )

• mice treated for 4 weeks with 10mg/kg-day of rotenone starting at 13 weeks

• reduced activity

abnormal gait ( J:142713 )

• mice treated for 4 weeks with 10mg/kg-day of rotenone starting at 13 weeks

• tendency to stagger

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
aceruloplasminemia		DOID:0050711	OMIM:604290	J:142713