Phenotypes Associated with This Genotype

Genotype
MGI:3835308

• Allelic Composition: Hbb^tm2Unc/Hbb⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:64295 )

• 2% of body weight compared to 0.2% in wild-type mice

extramedullary hematopoiesis ( J:64295 )

• in the liver

abnormal erythrocyte morphology ( J:64295 )

decreased erythrocyte cell number ( J:64295 )

decreased hematocrit ( J:64295 )

increased hemoglobin concentration distribution width ( J:64295 )

decreased hemoglobin content ( J:64295 )

increased mean corpuscular hemoglobin concentration ( J:64295 )

decreased mean corpuscular volume ( J:64295 )

anisocytosis ( J:64295 )

poikilocytosis ( J:64295 )

increased spleen iron level ( J:64295 )

• by 5 months of age

liver/biliary system

increased liver iron level ( J:64295 )

• by 5 months of age

renal/urinary system

increased kidney iron level ( J:64295 )

• greater than in wild-type mice by 5 months of age

homeostasis/metabolism

increased spleen iron level ( J:64295 )

• by 5 months of age

increased kidney iron level ( J:64295 )

• greater than in wild-type mice by 5 months of age

increased liver iron level ( J:64295 )

• by 5 months of age

immune system

enlarged spleen ( J:64295 )

• 2% of body weight compared to 0.2% in wild-type mice

increased spleen iron level ( J:64295 )

• by 5 months of age

growth/size/body

enlarged spleen ( J:64295 )

• 2% of body weight compared to 0.2% in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
beta thalassemia		DOID:12241	OMIM:613985	J:64295