Phenotypes Associated with This Genotype

Genotype
MGI:3835346

cx23

• Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp; Tg(NES-TVA)J12Ech/0
• Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased glioma incidence ( J:52161 )

• 8 of 19 mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR develop gliomas unlike similarly treated wild-type mice

• 4 of 10 mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR and Cdk4 develop gliomas compared to 1 of 8 similarly treated wild-type mice

• 6 of 16 mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR, Cdk4, and bFGF develop gliomas compared to 3 of 29 similarly treated wild-type mice

hydrocephaly ( J:52161 )

• in mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR and bFGF or Cdk4

neoplasm

increased glioma incidence ( J:52161 )

• 8 of 19 mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR develop gliomas unlike similarly treated wild-type mice

• 4 of 10 mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR and Cdk4 develop gliomas compared to 1 of 8 similarly treated wild-type mice

• 6 of 16 mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR, Cdk4, and bFGF develop gliomas compared to 3 of 29 similarly treated wild-type mice