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Phenotypes Associated with This Genotype
Genotype
MGI:3835347
cx24
Allelic
Composition		 Cdkn2atm1Rdp/Cdkn2a+
Tg(NES-TVA)J12Ech/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation (6 available); any Cdkn2a mutation (66 available)
Tg(NES-TVA)J12Ech mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased glioma incidence ( J:52161 )
• 13 of 25 mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR develop gliomas unlike similarly treated wild-type mice

nervous system
increased glioma incidence ( J:52161 )
• 13 of 25 mice transfected with replication-competent ALV splice acceptor viral vector expressing a constitutively active EGFR develop gliomas unlike similarly treated wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory