Phenotypes Associated with This Genotype

Genotype
MGI:3835356

cx34

• Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp; Tg(GFAP-TVA)5Hev/0
• Genetic Background: involves: 129/Sv * BALB/c * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:125535 )

• after 84 days, mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB exhibit 30% compared to 85% survival in similarly treated Tg(GFAP-TVA)5Hev mice

neoplasm

increased glioma incidence ( J:125535 )

• 19 gliomas are discovered in 28 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB

increased oligodendroglioma incidence ( J:125535 )

• 5 grade II (similar to human oligodendroglioma) and 14 grade III (similar to anaplastic oligodendroglioma) tumors were found

nervous system

increased glioma incidence ( J:125535 )

• 19 gliomas are discovered in 28 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB

increased oligodendroglioma incidence ( J:125535 )

• 5 grade II (similar to human oligodendroglioma) and 14 grade III (similar to anaplastic oligodendroglioma) tumors were found