Phenotypes Associated with This Genotype

Genotype
MGI:3835361

• Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp; Tg(NES-TVA)J12Ech/0
• Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:125535 , J:153220 )

• after 84 days, mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB exhibit 15% compared to 50% survival in similarly treated Tg(NES-TVA)12Hev mice (J:125535)

• co delivery of RCAS-PDGFB and an antisense construct targeting Igfbp2 results in improved survival compared to mice infected with RCAS-PDGFB alone (J:153220)

neoplasm

increased glioma incidence ( J:125535 )

• 17 gliomas are discovered in 20 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB

• 6 grade II (similar to human oligodendroglioma) and 11 grade III (similar to anaplastic oligodendroglioma)

increased oligodendroglioma incidence ( J:153220 )

• infection with RCAS-PDGFB induces anaplastic oligodendrogliomas in 97% of mice

• tumors are highly aggressive and display multiple foci of pseudopalisading necrosis and microvascular proliferation

• co-infection with RCAS-PDGFB and RCAS-IGFBP2 results in tumors that are histopathologically identical to those in mice infected with only RCAS-PDGFB

• co delivery of RCAS-PDGFB and an antisense construct targeting Igfbp2 results in a primarily anaplastic oligodendrogliomas but 18% of tumors are lower grade oligodendrogliomas

nervous system

increased glioma incidence ( J:125535 )

• 17 gliomas are discovered in 20 mice transfected with replication-competent ALV splice acceptor viral vector expressing PDGFB

• 6 grade II (similar to human oligodendroglioma) and 11 grade III (similar to anaplastic oligodendroglioma)

increased oligodendroglioma incidence ( J:153220 )

• infection with RCAS-PDGFB induces anaplastic oligodendrogliomas in 97% of mice

• tumors are highly aggressive and display multiple foci of pseudopalisading necrosis and microvascular proliferation

• co-infection with RCAS-PDGFB and RCAS-IGFBP2 results in tumors that are histopathologically identical to those in mice infected with only RCAS-PDGFB

• co delivery of RCAS-PDGFB and an antisense construct targeting Igfbp2 results in a primarily anaplastic oligodendrogliomas but 18% of tumors are lower grade oligodendrogliomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
oligodendroglioma		DOID:3181		J:153220