Phenotypes Associated with This Genotype

Genotype
MGI:3835423

• Allelic Composition: Tg(C3-1-TAg)cJeg/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:46513 )

• some mice exhibit mixed tumors of the sweat glands and occasional nasal proliferative or neoplastic lesions develop from the nasal turbinate epithelium unlike in wild-type mice

increased mammary adenocarcinoma incidence ( J:46513 , J:52786 )

• by 6 months of age female mice develop multiple mammary ductular adenocarcinomas unlike in wild-type mice (J:46513)

• at 6 months, 10% of female mice exhibit lung metastasis (J:46513)

• adenocarcinoma cells exhibit increased rates of apoptosis compared to cells in wild-type mice (J:46513)

♀ • adenocarcinomas are classified as Dunn type B tumors (J:52786)

♀ • adenocarcinomas are classified as Dunn type B tumors nonporous females typically develop mammary adenocarcinoma at about 4 months of age while females that become pregnant show accelerated adenocarcinoma development (J:52786)

increased bulbourethral gland adenocarcinoma incidence ( J:46513 )

♂ • at 7 months, 10% to 20% male mice develop adenocarcinomas of the bulbourethral glands unlike in wild-type mice

increased prostate gland adenocarcinoma incidence ( J:46513 , J:52786 , J:72324 )

♂ • at 7 months in the ventral prostate and 11 months in the dorsolateral prostate (J:46513)

♂ • however, no metastasis is observed (J:46513)

♂ (J:52786)

♂ • at 7 months of age, 19% of mice exhibit carcinomas in the ventral lobe and 3% in the dorsolateral lobe unlike in wild-type mice (J:72324)

♂ • after 8 months, 40% of mice exhibit carcinomas in the ventral lobe and 13% in the dorsolateral lobe unlike in wild-type mice (J:72324)

♂ • the number of apoptotic cells in the prostate is greater than in wild-type mice (J:72324)

increased prostate intraepithelial neoplasia incidence ( J:46513 , J:72324 )

♂ • at 2 to 3 months, low-grade prostate intraepithelial neoplasia (PIN) is observed in the ventral and dorsolateral prostates unlike in wild-type mice (J:46513)

♂ • at 5 months, high-grade PIN is observed in both lobes unlike in wild-type mice (J:46513)

♂ • PIN lesions increase with age (J:46513)

♂ • at 5 to 6 months, mice develop low to high grade prostate intraepithelial neoplasia (PIN) unlike wild-type mice (J:72324)

♂ • low-grade PIN is observed in 83% and 100% of the ventral prostate at 2 to 3 months and 4 to 12 months, respectively, unlike wild-type mice (J:72324)

♂ • at 5 months, ventral and dorsolateral lobes exhibit high grade PIN unlike in wild-type mice (J:72324)

♂ • high-grade PIN is observed on 88% and 100% of mice at 5 to 8 months and more than 8 months, respectively, unlike in wild-type mice (J:72324)

♂ • numbers of PIN lesions increase with age in the ventral and dorsolateral lobes unlike wild-type mice (J:72324)

♂ • the number of apoptotic cells in the prostate is greater than in wild-type mice (J:72324)

increased urethral gland adenocarcinoma incidence ( J:46513 )

♂ • at 7 months, 10% to 20% male mice develop adenocarcinomas of the urethral glands unlike in wild-type mice

endocrine/exocrine glands

mammary gland duct hyperplasia ( J:52786 )

♀ • 2/3 of females develop atypical hyperplasia in the ducts and acini of mammary glands by 3 months of age

mammary gland alveolar hyperplasia ( J:52786 )

♀ • 2/3 of females develop atypical hyperplasia in the ducts and acini of mammary glands by 3 months of age

♀ • acini lesions resemble hyperplastic alveolar nodules

increased mammary adenocarcinoma incidence ( J:46513 , J:52786 )

• by 6 months of age female mice develop multiple mammary ductular adenocarcinomas unlike in wild-type mice (J:46513)

• at 6 months, 10% of female mice exhibit lung metastasis (J:46513)

• adenocarcinoma cells exhibit increased rates of apoptosis compared to cells in wild-type mice (J:46513)

♀ • adenocarcinomas are classified as Dunn type B tumors (J:52786)

♀ • adenocarcinomas are classified as Dunn type B tumors nonporous females typically develop mammary adenocarcinoma at about 4 months of age while females that become pregnant show accelerated adenocarcinoma development (J:52786)

mammary gland hyperplasia ( J:46513 )

♀ • at 2 months of age, female mice exhibit atypical ductal hyperplasias unlike in wild-type mice

♀ • hyperplastic cells exhibit increased rates of apoptosis compared to cells in wild-type mice

increased bulbourethral gland adenocarcinoma incidence ( J:46513 )

♂ • at 7 months, 10% to 20% male mice develop adenocarcinomas of the bulbourethral glands unlike in wild-type mice

prostate gland epithelial hyperplasia ( J:52786 )

♂ • hyperplastic changes in the epithelium of the dorsal/ventral regions of the prostate are seen as early as 3 months of age

increased prostate gland adenocarcinoma incidence ( J:46513 , J:52786 , J:72324 )

♂ • at 7 months in the ventral prostate and 11 months in the dorsolateral prostate (J:46513)

♂ • however, no metastasis is observed (J:46513)

♂ (J:52786)

♂ • at 7 months of age, 19% of mice exhibit carcinomas in the ventral lobe and 3% in the dorsolateral lobe unlike in wild-type mice (J:72324)

♂ • after 8 months, 40% of mice exhibit carcinomas in the ventral lobe and 13% in the dorsolateral lobe unlike in wild-type mice (J:72324)

♂ • the number of apoptotic cells in the prostate is greater than in wild-type mice (J:72324)

increased prostate intraepithelial neoplasia incidence ( J:46513 , J:72324 )

♂ • at 2 to 3 months, low-grade prostate intraepithelial neoplasia (PIN) is observed in the ventral and dorsolateral prostates unlike in wild-type mice (J:46513)

♂ • at 5 months, high-grade PIN is observed in both lobes unlike in wild-type mice (J:46513)

♂ • PIN lesions increase with age (J:46513)

♂ • at 5 to 6 months, mice develop low to high grade prostate intraepithelial neoplasia (PIN) unlike wild-type mice (J:72324)

♂ • low-grade PIN is observed in 83% and 100% of the ventral prostate at 2 to 3 months and 4 to 12 months, respectively, unlike wild-type mice (J:72324)

♂ • at 5 months, ventral and dorsolateral lobes exhibit high grade PIN unlike in wild-type mice (J:72324)

♂ • high-grade PIN is observed on 88% and 100% of mice at 5 to 8 months and more than 8 months, respectively, unlike in wild-type mice (J:72324)

♂ • numbers of PIN lesions increase with age in the ventral and dorsolateral lobes unlike wild-type mice (J:72324)

♂ • the number of apoptotic cells in the prostate is greater than in wild-type mice (J:72324)

increased urethral gland adenocarcinoma incidence ( J:46513 )

♂ • at 7 months, 10% to 20% male mice develop adenocarcinomas of the urethral glands unlike in wild-type mice

abnormal prostate gland physiology ( J:46513 )

♂ • prostate cells exhibit increased proliferation and apoptosis rates compared to in wild-type mice according to their degree of prostate intraepithelial neoplasia

reproductive system

increased bulbourethral gland adenocarcinoma incidence ( J:46513 )

♂ • at 7 months, 10% to 20% male mice develop adenocarcinomas of the bulbourethral glands unlike in wild-type mice

prostate gland epithelial hyperplasia ( J:52786 )

♂ • hyperplastic changes in the epithelium of the dorsal/ventral regions of the prostate are seen as early as 3 months of age

increased prostate gland adenocarcinoma incidence ( J:46513 , J:52786 , J:72324 )

♂ • at 7 months in the ventral prostate and 11 months in the dorsolateral prostate (J:46513)

♂ • however, no metastasis is observed (J:46513)

♂ (J:52786)

♂ • at 7 months of age, 19% of mice exhibit carcinomas in the ventral lobe and 3% in the dorsolateral lobe unlike in wild-type mice (J:72324)

♂ • after 8 months, 40% of mice exhibit carcinomas in the ventral lobe and 13% in the dorsolateral lobe unlike in wild-type mice (J:72324)

♂ • the number of apoptotic cells in the prostate is greater than in wild-type mice (J:72324)

increased prostate intraepithelial neoplasia incidence ( J:46513 , J:72324 )

♂ • at 2 to 3 months, low-grade prostate intraepithelial neoplasia (PIN) is observed in the ventral and dorsolateral prostates unlike in wild-type mice (J:46513)

♂ • at 5 months, high-grade PIN is observed in both lobes unlike in wild-type mice (J:46513)

♂ • PIN lesions increase with age (J:46513)

♂ • at 5 to 6 months, mice develop low to high grade prostate intraepithelial neoplasia (PIN) unlike wild-type mice (J:72324)

♂ • low-grade PIN is observed in 83% and 100% of the ventral prostate at 2 to 3 months and 4 to 12 months, respectively, unlike wild-type mice (J:72324)

♂ • at 5 months, ventral and dorsolateral lobes exhibit high grade PIN unlike in wild-type mice (J:72324)

♂ • high-grade PIN is observed on 88% and 100% of mice at 5 to 8 months and more than 8 months, respectively, unlike in wild-type mice (J:72324)

♂ • numbers of PIN lesions increase with age in the ventral and dorsolateral lobes unlike wild-type mice (J:72324)

♂ • the number of apoptotic cells in the prostate is greater than in wild-type mice (J:72324)

abnormal prostate gland physiology ( J:46513 )

♂ • prostate cells exhibit increased proliferation and apoptosis rates compared to in wild-type mice according to their degree of prostate intraepithelial neoplasia

integument

mammary gland duct hyperplasia ( J:52786 )

♀ • 2/3 of females develop atypical hyperplasia in the ducts and acini of mammary glands by 3 months of age

mammary gland alveolar hyperplasia ( J:52786 )

♀ • 2/3 of females develop atypical hyperplasia in the ducts and acini of mammary glands by 3 months of age

♀ • acini lesions resemble hyperplastic alveolar nodules

increased mammary adenocarcinoma incidence ( J:46513 , J:52786 )

• by 6 months of age female mice develop multiple mammary ductular adenocarcinomas unlike in wild-type mice (J:46513)

• at 6 months, 10% of female mice exhibit lung metastasis (J:46513)

• adenocarcinoma cells exhibit increased rates of apoptosis compared to cells in wild-type mice (J:46513)

♀ • adenocarcinomas are classified as Dunn type B tumors (J:52786)

♀ • adenocarcinomas are classified as Dunn type B tumors nonporous females typically develop mammary adenocarcinoma at about 4 months of age while females that become pregnant show accelerated adenocarcinoma development (J:52786)

mammary gland hyperplasia ( J:46513 )

♀ • at 2 months of age, female mice exhibit atypical ductal hyperplasias unlike in wild-type mice

♀ • hyperplastic cells exhibit increased rates of apoptosis compared to cells in wild-type mice

mortality/aging

premature death ( J:52786 )

• survival of males is longer than females, with 50% survival at around 4 months of age for females and 8 months of age for males

• all females die by 5-6 months of age, while all males die by 11 months of age

renal/urinary system

increased bulbourethral gland adenocarcinoma incidence ( J:46513 )

♂ • at 7 months, 10% to 20% male mice develop adenocarcinomas of the bulbourethral glands unlike in wild-type mice

increased urethral gland adenocarcinoma incidence ( J:46513 )

♂ • at 7 months, 10% to 20% male mice develop adenocarcinomas of the urethral glands unlike in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:52786
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:52786