Phenotypes Associated with This Genotype

Genotype
MGI:3835784

hm2

• Allelic Composition: Wfs1^tm1Koks/Wfs1^tm1Koks
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:145548 )

• 5% fewer than expected mice are born

behavior/neurological

behavior/neurological phenotype ( J:145548 )

N • mice exhibit normal contextual fear conditioning, active avoidance, forced-swim behavior, and coordination on a rotarod

abnormal behavioral response to addictive substance ( J:145548 )

• amphetamine-stimulated activity is decreased compared to in similarly-treated wild-type mice

• apomorphinne induces a greater increase in locomotor activity compared to in similarly treated wild-type mice

abnormal cued conditioning behavior ( J:145548 )

• mice exhibit increased freezing in a cued conditioning test compared to wild-type mice

decreased exploration in new environment ( J:145548 )

• following short-term isolation, mice exhibit reduced exploration in a light-dark box exploration test compared to similarly treated wild-type mice

• mice exhibit decreased exploration in an elevated-plus maze compared to wild-type mice

• however, treatment with diazepam increases exploratory behavior

abnormal spatial learning ( J:145548 )

• mice exhibit impaired reverse spatial learning in a Morris water maze compared to wild-type mice

abnormal eating behavior ( J:145548 )

• mice exhibit a longer latency to start eating compared to wild-type mice

increased anxiety-related response ( J:150666 )

• increase in stretch-attend postures

• increase in open arm avoidance and affected risk assessment behaviors in a plus maze

increased thigmotaxis ( J:150666 )

• increase in open arm avoidance in a plus maze

impaired swimming ( J:145548 )

• slower swim speed

decreased vertical activity ( J:145548 )

• in a dark room

decreased locomotor activity ( J:145548 )

• under bright lights, mice exhibit decreased locomotor activity compared to wild-type mice

increased locomotor activity ( J:145548 )

• apomorphinne induces a greater increase in locomotor activity compared to in similarly treated wild-type mice

analgesia ( J:145548 )

• mice exhibit a greater stress-induced analgesic effect compared to in simialrly treated wild-type mice

abnormal vocalization ( J:145548 )

• 15% to 50% of mice produce spontaneous vocalizations above 10 kHz unlike wild-type mice

• vocalizations increase under stressful conditions

• however, vocalizations can be blocked by the administration of diazepam

homeostasis/metabolism

increased circulating corticosterone level ( J:145548 )

• stress-induced increases in plasma corticosterone levels are greater than in similarly treated wild-type mice

impaired glucose tolerance ( J:145548 , J:157967 )

• 30 and 60 minutes following intraperitoneal injection of glucose, mice exhibit increased serum glucose levels compared to wild-type mice (J:145548)

growth/size/body

decreased body size ( J:145548 , J:157967 )

• male mice are occasionally very small (J:145548)

decreased body weight ( J:145548 , J:150666 , J:157967 )

• at 2 and 3 months of age (J:145548)

slow postnatal weight gain ( J:145548 )