Phenotypes Associated with This Genotype

Genotype
MGI:3835822

• Allelic Composition: Tg(Dspp-TGFB1)3Kul/?
• Genetic Background: FVB/N-Tg(Dspp-TGFB1)3Kul

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Gross tooth abnormalities in Tg(Dspp-TGFB1)3Kul/? mice

craniofacial

abnormal tooth mineralization ( J:118918 )

• mineralization of the incisors is reduced by about 90% compared to controls based on X-ray analysis

• molar mineralization is reduced by 62%

• calcium mineralization is unevenly distributed throughout the dentin and enamel

abnormal dentin morphology ( J:118918 )

• incisors have a highly disorganized odontoblast layer and irregular dentinal tubules all along the dentinal layer

brittle teeth ( J:118918 )

• teeth turn chalky-white and then fracture starting around 2 weeks of age

growth/size/body

abnormal tooth mineralization ( J:118918 )

• mineralization of the incisors is reduced by about 90% compared to controls based on X-ray analysis

• molar mineralization is reduced by 62%

• calcium mineralization is unevenly distributed throughout the dentin and enamel

abnormal dentin morphology ( J:118918 )

• incisors have a highly disorganized odontoblast layer and irregular dentinal tubules all along the dentinal layer

brittle teeth ( J:118918 )

• teeth turn chalky-white and then fracture starting around 2 weeks of age

skeleton

abnormal tooth mineralization ( J:118918 )

• mineralization of the incisors is reduced by about 90% compared to controls based on X-ray analysis

• molar mineralization is reduced by 62%

• calcium mineralization is unevenly distributed throughout the dentin and enamel

abnormal dentin morphology ( J:118918 )

• incisors have a highly disorganized odontoblast layer and irregular dentinal tubules all along the dentinal layer

brittle teeth ( J:118918 )

• teeth turn chalky-white and then fracture starting around 2 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dentin dysplasia		DOID:701	OMIM:125400 OMIM:125420	J:118918