Phenotypes Associated with This Genotype

Genotype
MGI:3836157

• Allelic Composition: Tg(MMTV-AURKA)#Cxd/?
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:145680 )

• mice that have given birth at least 5 times have increased risk of developing mammary tumors

• tumors first become visible at 9 months of age

• about 40% of mice develop mammary tumors consisting of adenocarcinomas or spindle cell carcinoma

• in contrast only about 8% of virgin mice develop mammary tumors over a two-year time frame

increased ovary tumor incidence ( J:145680 )

♀ • is noted in about 3% of mice that have given birth at least 5 times

increased kidney tumor incidence ( J:145680 )

• kidney tumor is observed in about 3% of mice that have given birth at least 5 times

cellular

polyploidy ( J:145680 )

• 25% of mammary epithelial cells from 4-month old mice are polyploidy and show premature chromatid segregation

• about half of mammary epithelial tumor cells are polyploidy

endocrine/exocrine glands

abnormal mammary gland epithelium morphology ( J:145680 )

♀ • 10% of mammary epithelial cells from 4-month old mice contain more than 2 centrosomes per nucleus compared to about 1% mammary epithelial cells from control mice

abnormal branching of the mammary ductal tree ( J:145680 )

♀ • parous mice over one year in age have more extensive ductal branching

mammary gland duct hyperplasia ( J:145680 )

♀ • mammary glands are visibly larger at 4 month of age

mammary gland alveolar hyperplasia ( J:145680 )

♀ • parous mice over one year in age have increased alveolization within the gland

increased mammary adenocarcinoma incidence ( J:145680 )

• mice that have given birth at least 5 times have increased risk of developing mammary tumors

• tumors first become visible at 9 months of age

• about 40% of mice develop mammary tumors consisting of adenocarcinomas or spindle cell carcinoma

• in contrast only about 8% of virgin mice develop mammary tumors over a two-year time frame

mammary gland hyperplasia ( J:145680 )

♀ • mammary epithelium at 2 months of age exhibit multiple layers of cells in contrast to the one or two cell layers found in control mice

♀ • parous mice have 4-fold more actively proliferating cells in the mammary epithelium than controls

increased ovary tumor incidence ( J:145680 )

♀ • is noted in about 3% of mice that have given birth at least 5 times

reproductive system

increased ovary tumor incidence ( J:145680 )

♀ • is noted in about 3% of mice that have given birth at least 5 times

uterus hyperplasia ( J:145680 )

♀ • is observed in mice that have given birth multiple times

integument

abnormal mammary gland epithelium morphology ( J:145680 )

♀ • 10% of mammary epithelial cells from 4-month old mice contain more than 2 centrosomes per nucleus compared to about 1% mammary epithelial cells from control mice

abnormal branching of the mammary ductal tree ( J:145680 )

♀ • parous mice over one year in age have more extensive ductal branching

mammary gland duct hyperplasia ( J:145680 )

♀ • mammary glands are visibly larger at 4 month of age

mammary gland alveolar hyperplasia ( J:145680 )

♀ • parous mice over one year in age have increased alveolization within the gland

increased mammary adenocarcinoma incidence ( J:145680 )

• mice that have given birth at least 5 times have increased risk of developing mammary tumors

• tumors first become visible at 9 months of age

• about 40% of mice develop mammary tumors consisting of adenocarcinomas or spindle cell carcinoma

• in contrast only about 8% of virgin mice develop mammary tumors over a two-year time frame

mammary gland hyperplasia ( J:145680 )

♀ • mammary epithelium at 2 months of age exhibit multiple layers of cells in contrast to the one or two cell layers found in control mice

♀ • parous mice have 4-fold more actively proliferating cells in the mammary epithelium than controls

renal/urinary system

increased kidney tumor incidence ( J:145680 )

• kidney tumor is observed in about 3% of mice that have given birth at least 5 times

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:145680