Phenotypes Associated with This Genotype

Genotype
MGI:3836158

• Allelic Composition: Tg(MMTV-AURKA)#Cxd/?; Trp53^tm1Tyj/Trp53⁺
• Genetic Background: involves: 129S2/SvPas * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:145680 )

• mammary tumors start to develop at 6 months of age

• 70% of mice have developed tumors by 18 months of age

cellular

polyploidy ( J:145680 )

• 25% of mammary epithelial cells from 4-month old mice are polyploidy and show premature chromatid segregation

• about half of mammary epithelial tumor cells are polyploidy

endocrine/exocrine glands

abnormal mammary gland epithelium morphology ( J:145680 )

♀ • 10% of mammary epithelial cells from 4-month old mice contain more than 2 centrosomes per nucleus compared to about 1% mammary epithelial cells from control mice

abnormal branching of the mammary ductal tree ( J:145680 )

♀ • parous mice over one year in age have more extensive ductal branching than transgenic mice not carrying a mutant Trp53 allele

mammary gland duct hyperplasia ( J:145680 )

♀ • parous mice have almost 6-fold more actively proliferating cells in the mammary epithelium than in controls

increased mammary adenocarcinoma incidence ( J:145680 )

• mammary tumors start to develop at 6 months of age

• 70% of mice have developed tumors by 18 months of age

integument

abnormal mammary gland epithelium morphology ( J:145680 )

♀ • 10% of mammary epithelial cells from 4-month old mice contain more than 2 centrosomes per nucleus compared to about 1% mammary epithelial cells from control mice

abnormal branching of the mammary ductal tree ( J:145680 )

♀ • parous mice over one year in age have more extensive ductal branching than transgenic mice not carrying a mutant Trp53 allele

mammary gland duct hyperplasia ( J:145680 )

♀ • parous mice have almost 6-fold more actively proliferating cells in the mammary epithelium than in controls

increased mammary adenocarcinoma incidence ( J:145680 )

• mammary tumors start to develop at 6 months of age

• 70% of mice have developed tumors by 18 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:145680