Phenotypes for Prph2 MGI:3836162 MGI Mouse

vision/eye

decreased retina rod cell number ( J:76490 )

abnormal photoreceptor outer segment morphology ( J:76490 )

• the outer segment of cells in the outer nuclear layer are disrupted in number and configuration compared to in wild-type mice

short photoreceptor outer segment ( J:76490 )

disorganized photoreceptor outer segment ( J:76490 )

• whorl-like structures

abnormal retina pigment epithelium morphology ( J:76490 )

• fewer phagosomes are observed than in wild-type mice despite ongoing phagocytosis of the membrane

thin retina outer nuclear layer ( J:76490 )

• at 6 months, the outer nuclear layer (ONL) is only 4 or 5 nuclei thick and there is evidence of ongoing depletion of cells unlike in wild-type mice

• at 10 months, the ONL is only 3 or 4 nuclei thick unlike in wild-type mice

increased susceptibility to age-related retinal degeneration ( J:76490 )

• mice exhibit 9 or 10 rows of photoreceptor nuclei at 2 months, 4 or 5 rows at 6 months, and 2 or 3 rows at 12 months of age indicating a faster degeneration than in Prph2^Rd2 heterozygotes

abnormal eye electrophysiology ( J:76490 )

• at 6 months, a- and b-wave of dark-adapted eyes are less than in wild-type mice

• at 10 months, a- and b-waves, maximal dark-adapted responses, and cone-isolated responses are further reduced

nervous system