Phenotypes Associated with This Genotype

Genotype
MGI:3836291

• Allelic Composition: Lgmn^tm1Ihn/Lgmn^tm1Ihn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Hepatosplenomegaly in Lgmn^tm1Ihn/Lgmn^tm1Ihn mice

hematopoietic system

extramedullary hematopoiesis ( J:143886 )

• spleens exhibit an increase in the number of erythrocytes, immature myeloid lineage cells, and Ter-119+ erythroid lineage cells compared to in wild-type mice

• mice exhibit an increase in non-T and non-B cells in the spleen unlike in wild-type mice

anemia ( J:143886 )

abnormal bone marrow cell morphology/development ( J:143886 )

• mice exhibit hemophagocytes in the bone marrow in an age-dependent manner unlike in wild-type mice

abnormal erythrocyte morphology ( J:143886 )

• red blood cells exhibit defective plasma membrane components compared to in wild-type mice

decreased erythrocyte cell number ( J:143886 )

decreased hematocrit ( J:143886 )

• in an age-dependent manner

decreased hemoglobin content ( J:143886 )

decreased mean corpuscular hemoglobin ( J:143886 )

decreased mean corpuscular hemoglobin concentration ( J:143886 )

increased lymphocyte cell number ( J:143886 )

• in an age-dependent manner

reticulocytosis ( J:143886 )

• in an age-dependent manner

abnormal spleen morphology ( J:143886 )

• spleens are darker in color than in wild-type mice

increased spleen weight ( J:143886 )

• 5 to 10 times larger in an age dependent manner

abnormal NK cell physiology ( J:143886 )

• impaired

abnormal macrophage physiology ( J:143886 )

• red blood cell phagocytic activity of macrophages is increased compared to in wild-type mice

homeostasis/metabolism

increased circulating tumor necrosis factor level ( J:143886 )

increased body temperature ( J:143886 )

liver/biliary system

increased liver weight ( J:143886 )

immune system

immune system phenotype ( J:143886 )

N • despite increased body temperature, mice exhibit normal inflammatory cytokine levels

increased lymphocyte cell number ( J:143886 )

• in an age-dependent manner

abnormal spleen morphology ( J:143886 )

• spleens are darker in color than in wild-type mice

increased spleen weight ( J:143886 )

• 5 to 10 times larger in an age dependent manner

abnormal NK cell physiology ( J:143886 )

• impaired

abnormal macrophage physiology ( J:143886 )

• red blood cell phagocytic activity of macrophages is increased compared to in wild-type mice

increased circulating tumor necrosis factor level ( J:143886 )

growth/size/body

increased liver weight ( J:143886 )

increased spleen weight ( J:143886 )

• 5 to 10 times larger in an age dependent manner

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lymphatic system disease		DOID:75		J:143886