Phenotypes Associated with This Genotype

Genotype
MGI:3836556

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Ptf1a^{tm1.1(cre)Cvw}/Ptf1a⁺; Tg(MUC1)79.24Gend/0
• Genetic Background: B6.Cg-Kras^tm4Tyj Ptf1a^{tm1.1(cre)Cvw} Tg(MUC1)79.24Gend

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased pancreas tumor incidence ( J:138959 , J:234412 )

• pancreatic tumors exhibit lower proliferation rates than in Kras^tm4Tyj Ptf1a^{tm1.1(cre)Cvw} Tg(MUC1)79.24Gend heterozygotes (J:138959)

• mice exhibit carcinoma in situ in the pancreas (J:234412)

increased pancreatic ductal adenocarcinoma incidence ( J:138959 )

• in 1 of 10 mice at 26 weeks

increased pancreatic intraepithelial neoplasia incidence ( J:138959 , J:234412 )

• mice exhibit high-grade PanIN lesions and carcinoma in situ, associated with disorganized glandular epithelium (J:234412)

• mice treated with gemcitabine exhibit normal pancreatic glandular structure 26 weeks after the beginning of treatment (J:234412)

decreased metastatic potential ( J:138959 )

• at 48 weeks, 6 of 10 mice develop metastasis to the lung and liver compared to 4 of 10 metastasis at 34 weeks of age in Kras^tm4Tyj Ptf1a^{tm1.1(cre)Cvw} Tg(MUC1)79.24Gend heterozygotes

endocrine/exocrine glands

increased pancreas tumor incidence ( J:138959 , J:234412 )

• pancreatic tumors exhibit lower proliferation rates than in Kras^tm4Tyj Ptf1a^{tm1.1(cre)Cvw} Tg(MUC1)79.24Gend heterozygotes (J:138959)

• mice exhibit carcinoma in situ in the pancreas (J:234412)

increased pancreatic ductal adenocarcinoma incidence ( J:138959 )

• in 1 of 10 mice at 26 weeks

increased pancreatic intraepithelial neoplasia incidence ( J:138959 , J:234412 )

• mice exhibit high-grade PanIN lesions and carcinoma in situ, associated with disorganized glandular epithelium (J:234412)

• mice treated with gemcitabine exhibit normal pancreatic glandular structure 26 weeks after the beginning of treatment (J:234412)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
adenoma		DOID:657		J:138959
pancreatic carcinoma		DOID:4905	OMIM:260350	J:234412