Phenotypes for Ctnnb1 Tg(Pbsn-cre)4Prb MGI:3836579 MGI Mouse

mortality/aging

premature death ( J:143034 )

• at 428 days

reproductive system

squamous metaplasia of preputial gland ( J:143034 )

• keratinized squamous metaplasia of the preputial gland develops at 100 days (67% incidence), 200 days and at end-point (100% incidence)

squamous metaplasia of bulbourethral gland ( J:143034 )

• mice exhibit keratinized squamous metaplasia in the bulbourethral gland with incidence of 67% at 100 days and 100% at 200 days unlike wild-type mice

increased prostate gland adenocarcinoma incidence ( J:143034 , J:284956 )

• at 200 days, mice develop adenocarcinoma foci (J:143034)

• at end-point, 100% of mice develop diffuse and locally invasive adenocarcinoma unlike wild-type mice (J:143034)

• prostatic tumor tissues show changes consistent with prostatic intracystic adenocarcinomas (J:284956)

• 3 of 5 mice show intracystic adenocarcinoma at 6-9 months of age (J:284956)

• 9 of 12 mice show intracystic adenocarcinoma at 9 months or older, with 1 of 12 showing invasive adenocarcinoma (J:284956)

increased prostate intraepithelial neoplasia incidence ( J:143034 , J:284956 )

• at 100 days, mice exhibit diffuse prostate intraepithelial neoplasia-like keratinized squamous metaplasia unlike in wild-type mice (J:143034)

• at 200 days, mice exhibit high-grade prostate intraepithelial neoplasia-like keratinized squamous metaplasia unlike in wild-type mice (J:143034)

• mice develop PIN lesions starting at 4-6 weeks of age (J:284956)

• 4 of 4 mice develop low grade PIN before 6 months of age and 3 of 4 mice show high grade PIN before 6 months of age (J:284956)

• 5 of 5 mice develop high grade PIN at 6-9 months of age (J:284956)

neoplasm

increased prostate gland adenocarcinoma incidence ( J:143034 , J:284956 )

• at 200 days, mice develop adenocarcinoma foci (J:143034)

• at end-point, 100% of mice develop diffuse and locally invasive adenocarcinoma unlike wild-type mice (J:143034)

• prostatic tumor tissues show changes consistent with prostatic intracystic adenocarcinomas (J:284956)

• 3 of 5 mice show intracystic adenocarcinoma at 6-9 months of age (J:284956)

• 9 of 12 mice show intracystic adenocarcinoma at 9 months or older, with 1 of 12 showing invasive adenocarcinoma (J:284956)

increased prostate intraepithelial neoplasia incidence ( J:143034 , J:284956 )

• at 100 days, mice exhibit diffuse prostate intraepithelial neoplasia-like keratinized squamous metaplasia unlike in wild-type mice (J:143034)

• at 200 days, mice exhibit high-grade prostate intraepithelial neoplasia-like keratinized squamous metaplasia unlike in wild-type mice (J:143034)

• mice develop PIN lesions starting at 4-6 weeks of age (J:284956)

• 4 of 4 mice develop low grade PIN before 6 months of age and 3 of 4 mice show high grade PIN before 6 months of age (J:284956)

• 5 of 5 mice develop high grade PIN at 6-9 months of age (J:284956)

renal/urinary system

squamous metaplasia of urethral gland ( J:143034 )

• urethral keratinized squamous metaplasia develops in 17% at day 200 and 28% at end-points unlike in wild-type mice

endocrine/exocrine glands

squamous metaplasia of preputial gland ( J:143034 )

• keratinized squamous metaplasia of the preputial gland develops at 100 days (67% incidence), 200 days and at end-point (100% incidence)

squamous metaplasia of bulbourethral gland ( J:143034 )

• mice exhibit keratinized squamous metaplasia in the bulbourethral gland with incidence of 67% at 100 days and 100% at 200 days unlike wild-type mice

increased prostate gland adenocarcinoma incidence ( J:143034 , J:284956 )

• at 200 days, mice develop adenocarcinoma foci (J:143034)

• at end-point, 100% of mice develop diffuse and locally invasive adenocarcinoma unlike wild-type mice (J:143034)

• prostatic tumor tissues show changes consistent with prostatic intracystic adenocarcinomas (J:284956)

• 3 of 5 mice show intracystic adenocarcinoma at 6-9 months of age (J:284956)

• 9 of 12 mice show intracystic adenocarcinoma at 9 months or older, with 1 of 12 showing invasive adenocarcinoma (J:284956)

increased prostate intraepithelial neoplasia incidence ( J:143034 , J:284956 )

• at 100 days, mice exhibit diffuse prostate intraepithelial neoplasia-like keratinized squamous metaplasia unlike in wild-type mice (J:143034)

• at 200 days, mice exhibit high-grade prostate intraepithelial neoplasia-like keratinized squamous metaplasia unlike in wild-type mice (J:143034)

• mice develop PIN lesions starting at 4-6 weeks of age (J:284956)

• 4 of 4 mice develop low grade PIN before 6 months of age and 3 of 4 mice show high grade PIN before 6 months of age (J:284956)

• 5 of 5 mice develop high grade PIN at 6-9 months of age (J:284956)

squamous metaplasia of urethral gland ( J:143034 )

• urethral keratinized squamous metaplasia develops in 17% at day 200 and 28% at end-points unlike in wild-type mice

integument

squamous metaplasia of preputial gland ( J:143034 )

• keratinized squamous metaplasia of the preputial gland develops at 100 days (67% incidence), 200 days and at end-point (100% incidence)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:143034

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

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