Phenotypes Associated with This Genotype

Genotype
MGI:3836915

• Allelic Composition: Sord^C57BL/Lia/Sord^C57BL/Lia
• Genetic Background: involves: C57BL/LiA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens morphology ( J:142446 )

• levels of sorbitol in the lens of 2 month old mice are very high (4.18 nmol/mg nmol/mg vs. 0.17 nmol/mg for wild-type)

cataract ( J:142446 )

• 5% of mice develop cataracts around 6 months of age

• 13 months after birth, rate of cataract incidence increases

• by 17 months of age, 69% of mice have cataracts

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract		DOID:83	OMIM:601371 OMIM:PS116200	J:142446