Phenotypes Associated with This Genotype

Genotype
MGI:3836920

• Allelic Composition: Igh-J^{tm2(3H9-VDJ*)Mwg}/Igh-J⁺
• Genetic Background: B6.129P2-Igh-J^{tm2(3H9-VDJ*)Mwg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased marginal zone B cell number ( J:142389 )

• relative numbers of marginal B cells is increased more than 3-fold compared to wild-type controls

decreased B cell number ( J:142389 )

• mice have 2.4-fold fewer B cells than controls

spleen hypoplasia ( J:142389 )

• spleen has 1.6-fold fewer B cells than controls

increased anti-double stranded DNA antibody level ( J:142389 )

• anti-dsDNA antibodies of the IgG2a isotype are detected in the sera of mice with levels dropping between 6 and 12 months of age

• anti-dsDNA antibodies with IgM, IgG2b, IgG3 isotypes are also present in mice at 6 months of age

hematopoietic system

increased marginal zone B cell number ( J:142389 )

• relative numbers of marginal B cells is increased more than 3-fold compared to wild-type controls

decreased B cell number ( J:142389 )

• mice have 2.4-fold fewer B cells than controls

spleen hypoplasia ( J:142389 )

• spleen has 1.6-fold fewer B cells than controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:142389