Analysis Tools
immune system
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• relative numbers of marginal B cells is increased more than 3-fold compared to wild-type controls
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• spleen has 1.9- to 2.9- fold fewer spleen cells than controls
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• anti-dsDNA antibodies of the IgG2a isotype are detected in the sera of mice from 1 to 3 months of age
• anti-dsDNA antibodies with IgM, IgG2b, IgG3 isotypes are also present with levels of IgG3 extremly high compared to controls
• at 3 months of age, levels are higher than those found in 56R mice that have peripheral T cells
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hematopoietic system
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• relative numbers of marginal B cells is increased more than 3-fold compared to wild-type controls
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• spleen has 1.9- to 2.9- fold fewer spleen cells than controls
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| systemic lupus erythematosus | DOID:9074 |
OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 |
J:142389 | |
