Phenotypes Associated with This Genotype

Genotype
MGI:3836962

• Allelic Composition: Ptch1^tm1Mps/Ptch1⁺; Tg(Atoh1-GFP)1Jejo/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased medulloblastoma incidence ( J:144811 )

• 80-95% of tumor cells express GFP

• GFP⁺ tumor cells but not GFP^- are able to propagate tumors into immunocompromised hosts

nervous system

increased medulloblastoma incidence ( J:144811 )

• 80-95% of tumor cells express GFP

• GFP⁺ tumor cells but not GFP^- are able to propagate tumors into immunocompromised hosts

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
medulloblastoma		DOID:0050902	OMIM:155255	J:144811