Phenotypes Associated with This Genotype

Genotype
MGI:3837366

cn47

• Allelic Composition: Adrb2^tm1Kry/Adrb2^tm1Kry; Tg(Col1a1-cre)1Kry/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal insulin secretion ( J:145998 )

• mice treated intracerebroventricularly with leptin fail to exhibit a decrease in glucose-stimulated insulin secretion as in wild-type mice

decreased circulating glucose level ( J:145998 )

• mice exhibit postprandial low blood glucose levels compared to in wild-type mice

increased circulating insulin level ( J:145998 )

• mice exhibit elevated serum insulin levels compared to in wild-type mice that could not be increased by treatment with propranolol as in wild-type mice

• mice treated intracerebroventricularly with leptin fail to exhibit a decrease in glucose-stimulated circulating insulin levels as in wild-type mice

• however, insulin tolerance is normal

endocrine/exocrine glands

abnormal insulin secretion ( J:145998 )

• mice treated intracerebroventricularly with leptin fail to exhibit a decrease in glucose-stimulated insulin secretion as in wild-type mice