Analysis Tools
reproductive system
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• mice seem to produce litters less frequently than wild-type mice
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• mice seem to produce smaller litters than wild-type mice
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muscle
| N |
• despite abnormal skeletal muscle fiber morphology, mice do not exhibit regenerating fibers or denervation
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• skeletal muscle fibers are smaller in diameter
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• skeletal muscle fibers are more varied in diameter
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• skeletal muscle fibers have centrally located nuclei
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• mutant skeletal muscles exhibit a decrease in fast and an increase in slow myosin heavy chain isoform expression
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nervous system
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• myelinated axons in the L4 ventral roots exhibit decreased diameter compared to in wild-type mice
• however, the number of axons is normal
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behavior/neurological
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• on a wire hang test, mice exhibit reduced latency to fall compared to wild-type mice
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• grip strength is reduced 17% compared to in wild-type mice
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growth/size/body
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• at 8 weeks and at later ages, male mice are 10% heavier than wild-type mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autosomal recessive limb-girdle muscular dystrophy type 2H | DOID:0110282 |
OMIM:254110 |
J:146155 | |
