Phenotypes Associated with This Genotype

Genotype
MGI:3837707

• Allelic Composition: Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺; Wap^tm1(cre)Arge/Wap⁺
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Histology and immunophenotyping of mammary carcinomas in Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺ Wap^tm1(cre)Arge/Wap⁺ mice

mortality/aging

decreased tumor-free survival time ( J:146290 )

• median tumor-free survival of lactating female mice is 9 days from the first parturition

neoplasm

increased mammary gland tumor incidence ( J:146290 )

• lactating female mice develop adenocarcinomas, and pale, squamous, and spindle cell carcinomas

• within 2 days to 2 months of first delivery, lactating females develop palpable multifocal, fully invasive tumors of the mammary gland unlike wild-type mice

• median tumor-free survival of lactating female mice is 9 days from the first parturition

• however, treatment with picropodophyllin decreases tumor mass

increased mammary adenocarcinoma incidence ( J:146290 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:146290 )

• within 2 days to 2 months of first delivery, lactating females develop palpable multifocal, fully invasive tumors of the mammary gland unlike wild-type mice

• median tumor-free survival of lactating female mice is 9 days from the first parturition

• lactating female mice develop adenocarcinomas, and pale, squamous, and spindle cell carcinomas

• however, treatment with picropodophyllin decreases tumor mass

increased mammary adenocarcinoma incidence ( J:146290 )

integument

increased mammary gland tumor incidence ( J:146290 )

• within 2 days to 2 months of first delivery, lactating females develop palpable multifocal, fully invasive tumors of the mammary gland unlike wild-type mice

• median tumor-free survival of lactating female mice is 9 days from the first parturition

• lactating female mice develop adenocarcinomas, and pale, squamous, and spindle cell carcinomas

• however, treatment with picropodophyllin decreases tumor mass

increased mammary adenocarcinoma incidence ( J:146290 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:146290