Phenotypes Associated with This Genotype

Genotype
MGI:3837857

• Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp; Col1a1^{tm1(CAG-EGFR)Char}/Col1a1^{tm2(CAG-EGFR*)Char}; Pten^tm1Hwu/Pten^tm1Hwu
• Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:146494 )

• no mice surviving tumor-free beyond 15 weeks following intracranial injection of an adenoviral cre unlike similarly treated Col1a1^{tm2(CAG-EGFR*)Char} or Col1a1^{tm1(CAG-EGFR)Char} homozygotes that do not develop tumors

neoplasm

increased glioblastoma incidence ( J:146494 )

• following intracranial injection of an adenoviral cre, mice develop glioblastoma multiforme with no mice surviving tumor-free beyond 13 weeks unlike similarly treated Col1a1^{tm2(CAG-EGFR*)Char} or Col1a1^{tm1(CAG-EGFR)Char} homozygotes that do not develop tumors

nervous system

increased glioblastoma incidence ( J:146494 )

• following intracranial injection of an adenoviral cre, mice develop glioblastoma multiforme with no mice surviving tumor-free beyond 13 weeks unlike similarly treated Col1a1^{tm2(CAG-EGFR*)Char} or Col1a1^{tm1(CAG-EGFR)Char} homozygotes that do not develop tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
high grade glioma		DOID:3070	OMIM:PS137800	J:146494