Phenotypes Associated with This Genotype

Genotype
MGI:3838153

• Allelic Composition: Tg(Myh7-RARA/lacZ)30Mcco/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

pregnancy-related premature death ( J:146424 )

• female mice die before or shortly after delivering a second consecutive pregnancy

reproductive system

reduced male fertility ( J:146424 )

♂ • male mice are unable to breed after 4 to 6 months of age

cardiovascular system

increased myocardial fiber size ( J:146424 )

• at 2 months of age, mice exhibit myofiber hypertrophy that is more pronounced with age unlike in wild-type mice

papillary muscle hypoplasia ( J:146424 )

• papillary muscles are attenuated

thin myocardium ( J:146424 )

enlarged heart ( J:146424 )

• at 1 to 7 months of age, mice exhibit mild cardiomegaly unlike in wild-type mice

abnormal heart left ventricle morphology ( J:146424 )

• mice exhibit trabeculations associated with the interior surface of the left ventricle unlike in wild-type mice

increased heart left ventricle weight ( J:146424 )

• increased size and mass

increased heart right ventricle size ( J:146424 )

dilated heart ventricle ( J:146424 )

• biventricular dilation

dilated heart left ventricle ( J:146424 )

abnormal cardiovascular system physiology ( J:146424 )

• maximum rate of pressure development and relaxation rates are reduced compared to in wild-type mice

• the Starling responses in a Frank-Starling relationship graph are compromised with a severe decrease in slope compared to wild-type mice

dilated cardiomyopathy ( J:146424 )

decreased cardiac muscle contractility ( J:146424 )

• the first derivative of the increase in left ventricle systolic pressure with respect to time, a measure of contractility, is decreased 63% compared to in wild-type mice

• fractional shortening and the velocity of fiber shortening are reduced compared to in wild-type mice

decreased heart left ventricle muscle contractility ( J:146424 )

• left ventricular contractility is decreased compared to in wild-type hearts

abnormal cardiac muscle relaxation ( J:146424 )

• the first derivative of the decrease in left ventricular systolic pressure with respect to time, a measure of relaxation, is decreased 64% compared to in wild-type hearts

congestive heart failure ( J:146424 )

• mice express markers of cardiac failure unlike wild-type mice

homeostasis/metabolism

abnormal atrial thrombosis ( J:146424 )

• large chronic left atria thrombus

muscle

increased myocardial fiber size ( J:146424 )

• at 2 months of age, mice exhibit myofiber hypertrophy that is more pronounced with age unlike in wild-type mice

papillary muscle hypoplasia ( J:146424 )

• papillary muscles are attenuated

thin myocardium ( J:146424 )

dilated cardiomyopathy ( J:146424 )

decreased cardiac muscle contractility ( J:146424 )

• the first derivative of the increase in left ventricle systolic pressure with respect to time, a measure of contractility, is decreased 63% compared to in wild-type mice

• fractional shortening and the velocity of fiber shortening are reduced compared to in wild-type mice

decreased heart left ventricle muscle contractility ( J:146424 )

• left ventricular contractility is decreased compared to in wild-type hearts

abnormal cardiac muscle relaxation ( J:146424 )

• the first derivative of the decrease in left ventricular systolic pressure with respect to time, a measure of relaxation, is decreased 64% compared to in wild-type hearts

growth/size/body

enlarged heart ( J:146424 )

• at 1 to 7 months of age, mice exhibit mild cardiomegaly unlike in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy		DOID:12930	OMIM:PS115200	J:146424