Phenotypes Associated with This Genotype

Genotype
MGI:3838162

• Allelic Composition: Cdkn1c^tm1Kat/Cdkn1c^tm1Kat
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

increased urine protein level ( J:102331 )

• by day 17.5 of pregnancy, protein secretion is 5 times greater than in pregnant wild-type mice

• however, after deliver protein secretion is normal

abnormal renal glomerulus morphology ( J:102331 )

• glomeruli are enlarged and irregularly shaped with increased subendothelial and mesangial depositions in glomeruli capillaries by day 17.5 of pregnancy unlike in pregnant wild-type mice

cortical renal glomerulopathies ( J:102331 )

• some pregnant mice exhibit nephrosclerosis unlike pregnant wild-type mice

abnormal renal tubule morphology ( J:102331 )

• fibroid and hyaline deposits are observed in the proximal and distal tubules of pregnant mice unlike in pregnant wild-type mice

embryo

abnormal trophoblast giant cell morphology ( J:102331 )

• fewer giant cells invade to maternal vessels at the maternal-fetal interface compared to in wild-type mice

abnormal placenta labyrinth morphology ( J:102331 )

• the labyrinthine space is narrow unlike in wild-type mice due to increased proliferation of spongio- and labyrinthine trophoblasts

increased placenta weight ( J:102331 )

cardiovascular system

increased systemic arterial systolic blood pressure ( J:102331 )

• systolic blood pressure increases at E9.5 through delivery before retuning to normal unlike pregnant wild-type mice that maintain normal blood pressure throughout pregnancy

• however, after delivery mice exhibit normal blood pressure

hematopoietic system

thrombocytopenia ( J:102331 )

• platelet counts are decreased to 48% of counts in pregnant wild-type by day 17 of pregnancy

homeostasis/metabolism

increased urine protein level ( J:102331 )

• by day 17.5 of pregnancy, protein secretion is 5 times greater than in pregnant wild-type mice

• however, after deliver protein secretion is normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pre-eclampsia		DOID:10591	OMIM:189800 OMIM:609402 OMIM:609403 OMIM:609404 OMIM:614592	J:102331