Phenotypes Associated with This Genotype

Genotype
MGI:3838163

• Allelic Composition: Cdkn1c^tm1Kat/Cdkn1c⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

increased urine protein level ( J:102331 )

• when this allele is maternally inherited, protein secretion is 2.8 times greater by day 17.5 of pregnancy than in pregnant wild-type mice

• however, protein secretion is normal after delivery or when this allele is inherited parentally

abnormal renal glomerulus morphology ( J:102331 )

• when this allele is maternally inherited, glomeruli are enlarged and irregularly shaped with increased subendothelial and mesangial depositions in glomeruli capillaries by day 17.5 of pregnancy unlike in pregnant wild-type mice

cortical renal glomerulopathies ( J:102331 )

• when this allele is maternally inherited, some pregnant mice exhibit nephrosclerosis unlike pregnant wild-type mice

abnormal renal tubule morphology ( J:102331 )

• when this allele is maternally inherited, fibroid and hyaline deposits are observed in the proximal and distal tubules of pregnant mice unlike in pregnant wild-type mice

embryo

abnormal trophoblast giant cell morphology ( J:102331 )

• when this allele is maternally inherited, fewer giant cells invade to maternal vessels at the maternal-fetal interface compared to in wild-type mice

abnormal placenta labyrinth morphology ( J:102331 )

• when this allele is maternally inherited, the labyrinthine space is narrow unlike in wild-type mice due to increased proliferation of spongio- and labyrinthine trophoblasts

increased placenta weight ( J:102331 )

• when this allele is maternally inherited

cardiovascular system

increased systemic arterial systolic blood pressure ( J:102331 )

• when this allele is maternally inherited, systolic blood pressure increases at E9.5 through delivery before retuning to normal unlike pregnant wild-type mice that maintain normal blood pressure throughout pregnancy

• however, blood pressure is normal after delivery or when this allele is inherited parentally

hematopoietic system

thrombocytopenia ( J:102331 )

• when this allele is maternally inherited, platelet counts are decreased to 55% of counts in pregnant wild-type by day 17 of pregnancy

• however, platelet counts are normal when this allele is inherited parentally

homeostasis/metabolism

increased urine protein level ( J:102331 )

• when this allele is maternally inherited, protein secretion is 2.8 times greater by day 17.5 of pregnancy than in pregnant wild-type mice

• however, protein secretion is normal after delivery or when this allele is inherited parentally

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pre-eclampsia		DOID:10591	OMIM:189800 OMIM:609402 OMIM:609403 OMIM:609404 OMIM:614592	J:102331