Phenotypes Associated with This Genotype

Genotype
MGI:3838164

• Allelic Composition: Tg(ATXN3*)67.2Cce/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

slow postnatal weight gain ( J:76495 )

• mice have slower weight gain with a 8% weight reduction by 48 weeks of age compared to controls

behavior/neurological

limb grasping ( J:76495 )

• mice clasp fore- and hind-limbs when lifted by the tail

tremors ( J:76495 )

• mice have mild tremors

abnormal gait ( J:76495 )

• mice have a wide gait and a lowered pelvis during grid climbing

decreased locomotor activity ( J:76495 )

• mice are mildly less active than controls starting at 4 weeks of age

nervous system

Purkinje cell degeneration ( J:76495 )

• Purkinje cell loss is evident

gliosis ( J:76495 )

• mice have mild gliosis in areas of neuronal loss

neuronal intranuclear inclusions ( J:76495 )

• is observed in 30% of pontine nuclei and 20% of dentate nuclei

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Machado-Joseph disease		DOID:1440	OMIM:109150	J:76495