Phenotypes Associated with This Genotype

Genotype
MGI:3838167

• Allelic Composition: Tg(ATXN3*)84.2Cce/Tg(ATXN3*)84.2Cce
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

slow postnatal weight gain ( J:76495 )

• mice have slower weight gain with a 40% weight reduction by 35 weeks of age compared to controls

• mice weigh 27% less than controls at weaning and 39% less at 20 weeks of age

behavior/neurological

limb grasping ( J:76495 )

• some mice clasp fore- and hind-limbs when lifted by the tail by 16 weeks of age

tremors ( J:76495 )

• mice have marked tremors

abnormal gait ( J:76495 )

• mice have a prominent wide gait and a lowered pelvis during grid climbing

decreased locomotor activity ( J:76495 )

• mice are less active and inquisitive than controls

positive geotaxis ( J:76495 )

• mice have no negative geotaxis after 12 weeks of age

nervous system

hippocampal neuron degeneration ( J:76495 )

• 30% of dentate neurons are lost in these mice by 12 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Machado-Joseph disease		DOID:1440	OMIM:109150	J:76495