Phenotypes Associated with This Genotype

Genotype
MGI:3838187

ht2

• Allelic Composition: Ttr^tm2(TTR)Kymm/Ttr⁺
• Genetic Background: B6.Cg-Ttr^tm2(TTR)Kymm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating thyroxine level ( J:146510 )

• circulating T4 levels are decreased by around 10% compared to controls

decreased circulating triiodothyronine level ( J:146510 )

• circulating levels of T3 are slightly decreased in the blood similar to levels in null homozygotes

abnormal circulating protein level ( J:146510 )

• circulating retinol binding protein levels are reduced by over 10%

abnormal retinol level ( J:146510 )

• serum retinol levels are reduced by around 40% compared to controls