About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3838352
Allelic
Composition
Agpat2tm1Garg/Agpat2tm1Garg
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agpat2tm1Garg mutation (0 available); any Agpat2 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only 20% of mice survive past 3 weeks of age
• 80% of mice die by 3 weeks of age with the majority of these mice dieing within the first week of life

homeostasis/metabolism
N
• mice exhibit normal plasma triglyceride, cholesterol levels, creatine kinase and creatinine level, and consumption of oxygen and carbon dioxide
• mice emit 22% more carbon dioxide than wild-type mice
• 24% more than wild-type mice
• the respiratory exchange ratio is reduced, particularly during the dark phase, compared to in wild-type mice
• in female, but not male, mice
• as early as day 1 after birth
• during an oral glucose tolerance test whether fasted or not (J:231617)
• male, but not female, mice exhibit increased glucose clearance compared with wild-type mice
• hyperinsulinic-insulin resistant whether fasted or not (J:231617)
• however, mice exhibit normal glucose tolerance and normal insulin sensitivity in a meal tolerance test (J:231617)
• in female, but not male, mice
• in males but not females
• fatty acid synthesis is increased compared to in wild-type mice
• when fed a low fat diet, mice exhibit decreased serum fatty acid levels compared to similarly treated wild-type mice and mice fed a regular diet
• when fed a standard diet, female mice exhibit decreased serum fatty acid levels compared to in wild-type mice
• male mice exhibit an increase in liver phosphatidyl ethanolamine (PE), phosphatidyl choline (PC), and phosphatidyl serine (PS) levels compared to in wild-type mice
• levels of diacylglyceride are decreased in male mice compared to in wild-type mice
• however, female mice exhibit normal liver phospholipids levels
• triglyceride levels are increased 6.4-fold in males compared to in wild-type mice (J:146649)
• triglyceride levels are increased 2.1-fold in females compared to in wild-type mice (J:146649)
• however, liver triglyceride levels are decreased in low fat diet fed male mice (by 56%) and female mice compared to in mice fed a regular diet (J:146649)
• triglyceride synthesis in hepatocytes is increased compared to in wild-type cells (J:146649)
• in female and male mice (J:231617)

adipose tissue
• white and brown adipose are completely absent
• 2% compared to 24% to 29% in wild-type mice

behavior/neurological
• 3.7 times more than wild-type mice
• in male and female mice
• mice intake 85% more energy than wild-type mice (J:146649)
• in female, but not male, mice (J:231617)
• particularly during the dark phase

liver/biliary system
• livers are twice as heavy as in wild-type mice at 8 to 10 weeks of age (J:146649)
• however, liver weights are decreased in low fat diet fed male (by 28%) and female mice compared to mice fed a standard diet (J:146649)
• in female and male mice at 16 weeks (J:231617)
• triglyceride levels are increased 6.4-fold in males compared to in wild-type mice (J:146649)
• triglyceride levels are increased 2.1-fold in females compared to in wild-type mice (J:146649)
• however, liver triglyceride levels are decreased in low fat diet fed male mice (by 56%) and female mice compared to in mice fed a regular diet (J:146649)
• triglyceride synthesis in hepatocytes is increased compared to in wild-type cells (J:146649)
• in female and male mice (J:231617)

endocrine/exocrine glands

renal/urinary system
• at 8 to 10 weeks of age

hematopoietic system
• at 8 to 10 weeks of age

digestive/alimentary system
• elongated at 8 to 10 weeks of age

immune system
• at 8 to 10 weeks of age

integument

growth/size/body
• in female and male mice
• at 8 to 10 weeks of age
• livers are twice as heavy as in wild-type mice at 8 to 10 weeks of age (J:146649)
• however, liver weights are decreased in low fat diet fed male (by 28%) and female mice compared to mice fed a standard diet (J:146649)
• in female and male mice at 16 weeks (J:231617)
• at 8 to 10 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
congenital generalized lipodystrophy type 1 DOID:0111135 OMIM:608594
J:146649


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory