Phenotypes Associated with This Genotype

Genotype
MGI:3838390

hm2

• Allelic Composition: Fancd2^{Gt(OST57859)Lex}/Fancd2^{Gt(OST57859)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:146616 )

• phenotype is stated to be similar to that of Fancd2^tm1Hou homozygotes; however no data is presented in J:146616

growth/size/body

decreased body weight ( J:146616 )

postnatal growth retardation ( J:146616 )

fetal growth retardation ( J:146616 )

endocrine/exocrine glands

decreased mature ovarian follicle number ( J:146616 )

♀

abnormal seminiferous tubule morphology ( J:146616 )

♂

small testis ( J:146616 )

♂

reproductive system

oligozoospermia ( J:146616 )

♂

abnormal spermatocyte morphology ( J:146616 )

♂

abnormal male meiosis ( J:146616 )

♂

decreased mature ovarian follicle number ( J:146616 )

♀

abnormal seminiferous tubule morphology ( J:146616 )

♂

small testis ( J:146616 )

♂

neoplasm

increased adenoma incidence ( J:146616 )

increased carcinoma incidence ( J:146616 )

vision/eye

microphthalmia ( J:146616 )

cellular

oligozoospermia ( J:146616 )

♂

abnormal spermatocyte morphology ( J:146616 )

♂

abnormal male meiosis ( J:146616 )

♂