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Phenotypes Associated with This Genotype
Genotype
MGI:3838391
Allelic
Composition		 Fancd2Gt(OST57859)Lex/Fancd2Gt(OST57859)Lex
Usp1tm1.1Ada/Usp1tm1.1Ada
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fancd2Gt(OST57859)Lex mutation (0 available); any Fancd2 mutation (82 available)
Usp1tm1.1Ada mutation (0 available); any Usp1 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased cellular sensitivity to ionizing radiation ( J:146616 )
• bone marrow cells have decreased survival after exposure to ionizing radiation compared to controls that are homozygote null for just one allele
induced chromosome breakage ( J:146616 )
• bone marrow cell are also hypersensitive to mitomycin C treatment (MMC) with with increased numbers of chromosome breaks and decreased survival compared to controls that are homozygote null for just one allele

endocrine/exocrine glands
ovary atrophy ( J:146616 )
• female mice have severe atrophy of the ovaries

reproductive system
ovary atrophy ( J:146616 )
• female mice have severe atrophy of the ovaries

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Fanconi anemia complementation group D2 DOID:0111083 OMIM:227646
 J:146616

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory