Phenotypes Associated with This Genotype

Genotype
MGI:3838963

• Allelic Composition: Tg(Camk2a-tTA)1Mmay/0; Tg(tetO-DISC1*)1001Plet/0
• Genetic Background: involves: C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial reference memory ( J:146881 )

♀ • spatial memory in females is impaired in probe trials, with females spending less time in the target quadrant where the platform had previously been

increased locomotor activity ( J:146881 )

♂ • male mutants show higher degree of spontaneous locomotor activity than wild-type littermate controls during a 20-hour period

abnormal social/conspecific interaction behavior ( J:146881 )

♂ • male mutants spend significantly less time in non-aggressive social interaction with other males

increased aggression towards mice ( J:146881 )

♂ • males display increased aggressiveness toward other males, with an increase in number of attacks

nervous system

abnormal lateral ventricle morphology ( J:146881 )

• volume is significantly increased, with no change in total brain volume

abnormal neuron morphology ( J:146881 )

• cultured control neurons grow more complex neurite arbors than mutant neurons (for 20-100 um rings centered on neuron soma)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia 9		DOID:0070085	OMIM:604906	J:146881