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Phenotypes Associated with This Genotype
Genotype
MGI:3838967
Allelic
Composition
Oatrhg/Oatrhg
Genetic
Background
B6Ei;AKR-Oatrhg/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oatrhg mutation (1 available); any Oat mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Small size and retarded hair growth in Oatrhg/Oatrhg mice

nervous system
• somewhat shortened and disorganized at 12 months of age

mortality/aging
• breeding heterozygotes with homozygotes yields only 41% mutant offspring rather than the predicted 50%

growth/size/body
• although normal size at birth, homozygotes are smaller than littermates shortly thereafter then begin to catch up in size at 4 weeks of age

pigmentation
• at one week of age homozygotes have no pigment, and older homozygotes have white at the tips of the hair
• at 12 months of age the retinal pigment epithelium shows degeneration with irregular swelling and frequent doming, with occassional migration of retinal pigment epithelial cells into the outer segment layer

homeostasis/metabolism
• plasma ornithine is increased to approximately 1000 uM

vision/eye
• somewhat shortened and disorganized at 12 months of age
• at 12 months of age the retinal pigment epithelium shows degeneration with irregular swelling and frequent doming, with occassional migration of retinal pigment epithelial cells into the outer segment layer
• cataracts are found 2 month and 3.5 month old homozygotes

hearing/vestibular/ear
N
• two of two homozygotes assessed show normal auditory brain stem response

integument
• at one week of age homozygotes have no pigment, and older homozygotes have white at the tips of the hair
• at two weeks of age homozygotes still have no hair and hair begins to grow in at 3 weeks of age
• after 1 month of age the fur has a ruffled appearance due to growing in different directions
• follicular dysplasia

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
gyrate atrophy DOID:1415 OMIM:258870
J:213842


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory