Phenotypes Associated with This Genotype

Genotype
MGI:3838993

cx12

• Allelic Composition: Il6^tm1Kopf/Il6^tm1Kopf; Inpp5d^tm1Rkh/Inpp5d^tm1Rkh
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal lymphopoiesis ( J:117320 )

• the percentage of prolymphocyte in the bone marrow is slightly less than wild-type (35% versus 27%)

decreased pro-B cell number ( J:117320 )

• the percentage of CD19⁺ B cell progenitors in the bone marrow is decreased by almost 4-fold

abnormal myelopoiesis ( J:117320 )

• 78% of mutant bone marrow cells are Mac-1⁺ compared to 56% in wild-type

hematopoietic system

abnormal lymphopoiesis ( J:117320 )

• the percentage of prolymphocyte in the bone marrow is slightly less than wild-type (35% versus 27%)

decreased pro-B cell number ( J:117320 )

• the percentage of CD19⁺ B cell progenitors in the bone marrow is decreased by almost 4-fold

abnormal myelopoiesis ( J:117320 )

• 78% of mutant bone marrow cells are Mac-1⁺ compared to 56% in wild-type

abnormal hematopoietic stem cell morphology ( J:117320 )

• there is a 2-fold decrease in Lin^-c-Kit^loSca-1^lo population in the bone marrow that contains the hematopoietic stem cell population