Phenotypes Associated with This Genotype

Genotype
MGI:3839234

cx8

• Allelic Composition: Rxra^tm2Ipc/Rxra^tm2Ipc; Rxrb^tm1Mma/Rxrb^tm1Mma
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

embryo phenotype ( J:146761 )

N • unlike in mice null for both Rxra and Rxrb, placentas appear normal at E9.5

absent third pharyngeal arch artery ( J:146761 )

• absent at E9.5

third pharyngeal arch hypoplasia ( J:146761 )

• at E9.5, bilateral hypoplasia of the third branchial arches is seen

increased rhombomere 5 size ( J:146761 )

• enlargement of the fifth rhombomere is seen at E9.5

hearing/vestibular/ear

abnormal otic vesicle development ( J:146761 )

• supernumerary otic vesicles are present at E9.5

nervous system

increased rhombomere 5 size ( J:146761 )

• enlargement of the fifth rhombomere is seen at E9.5

cardiovascular system

absent third pharyngeal arch artery ( J:146761 )

• absent at E9.5

craniofacial

absent third pharyngeal arch artery ( J:146761 )

• absent at E9.5

third pharyngeal arch hypoplasia ( J:146761 )

• at E9.5, bilateral hypoplasia of the third branchial arches is seen