Analysis Tools
immune system
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• sera IgG2a levels are elevated more than 2-fold in mice with severe spontaneous arthritis
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• macrophages produce 6.5-fold more TNF in response to immunoglobulin aggregates compared to controls
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• macrophages produce 6.5-fold more TNF in response to immunoglobulin aggregates compared to controls
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• in mice over 20 weeks of age, 13 of 23 have anti-histone antibodies above background levels
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• 32% of mice develop a spontaneous form of arthritis between 20 and 50 weeks of age
• arthritis is characterized by severe ankylosis of the tibiotarsal and tarsophalangeal cartilage, loss of joint space and prominent periarticular new bone formation
• the arthritic joints contain synovial hyperplasia and proliferation, cartilage erosion, pannus formation, and joint space infiltrate
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• transgenic mice have an earlier onset of collagen-induced arthritis than controls despite having a protective H2 locus
• mean day of onset is 18 days versus 22 days in the susceptible DBA/1 strain
• 15% of mice develop arthritis with just one immunization of collagen compared to none in DBA/1 mice
• over 90% of mice develop arthritis within six days after a second injection of collagen compared to less then 10% of DBA/1 mice
• mice are also highly susceptible to an arthritis model initiated by injections of anti-collagen antibodies
• 100% of mice develop arthritis after injection of anti-collagen antibody while controls needed an LPS adjuvant in addition to the immunoglobulins to develop disease
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• mice have an age-related progression to severe glomerulonephritis
• few mice have the disease prior to 20 weeks of age, up to 80% have disease by 40 weeks of age, and all mice have disease over 40 weeks of age
• disease is first evident as multifocallymphoplasmacytic infiltrate in the renal interstitium mainly around major arcuate vessels
• more advanced disease was seen, with enlarged glomeruli, increased mesangial matrix and condensation of glomerular tufts
• disease is self-limiting as kidney function is never impaired
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• pneumonitis was found in 25% of mice between 12 to 40 weeks of age and increases to 100% in older mice
• disease is characterized by patches of perivascular inflammation with cellular aggregates of macrophages, lymphocytes, and plasma cells within alveolar walls
• in severe cases, up to 50% of the normal architecture of the lungs is obliterated
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renal/urinary system
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• mice have an age-related progression to severe glomerulonephritis
• few mice have the disease prior to 20 weeks of age, up to 80% have disease by 40 weeks of age, and all mice have disease over 40 weeks of age
• disease is first evident as multifocallymphoplasmacytic infiltrate in the renal interstitium mainly around major arcuate vessels
• more advanced disease was seen, with enlarged glomeruli, increased mesangial matrix and condensation of glomerular tufts
• disease is self-limiting as kidney function is never impaired
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• immunoglobulin deposition is noted in the kidney
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respiratory system
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• pneumonitis was found in 25% of mice between 12 to 40 weeks of age and increases to 100% in older mice
• disease is characterized by patches of perivascular inflammation with cellular aggregates of macrophages, lymphocytes, and plasma cells within alveolar walls
• in severe cases, up to 50% of the normal architecture of the lungs is obliterated
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skeleton
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• 32% of mice develop a spontaneous form of arthritis between 20 and 50 weeks of age
• arthritis is characterized by severe ankylosis of the tibiotarsal and tarsophalangeal cartilage, loss of joint space and prominent periarticular new bone formation
• the arthritic joints contain synovial hyperplasia and proliferation, cartilage erosion, pannus formation, and joint space infiltrate
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• transgenic mice have an earlier onset of collagen-induced arthritis than controls despite having a protective H2 locus
• mean day of onset is 18 days versus 22 days in the susceptible DBA/1 strain
• 15% of mice develop arthritis with just one immunization of collagen compared to none in DBA/1 mice
• over 90% of mice develop arthritis within six days after a second injection of collagen compared to less then 10% of DBA/1 mice
• mice are also highly susceptible to an arthritis model initiated by injections of anti-collagen antibodies
• 100% of mice develop arthritis after injection of anti-collagen antibody while controls needed an LPS adjuvant in addition to the immunoglobulins to develop disease
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hematopoietic system
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• sera IgG2a levels are elevated more than 2-fold in mice with severe spontaneous arthritis
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• macrophages produce 6.5-fold more TNF in response to immunoglobulin aggregates compared to controls
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| rheumatoid arthritis | DOID:7148 |
OMIM:180300 |
J:136516 | |
