Phenotypes Associated with This Genotype

Genotype
MGI:3839678

cx28

• Allelic Composition: Lepr^db/Lepr^db; Plin1^tm1Chan/Plin1^tm1Chan
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased susceptibility to age related obesity ( J:66267 )

• mice are resistant to the obesity caused by the Lepr^db background

• at a given age, mice weigh significantly less than Lepr^db homozygotes but more than wild-type controls

• MRI analysis finds the total lipid signal for these mice at 27% compared to 24% for wild-type and 63% for the Lepr^db homozygotes

homeostasis/metabolism

increased oxygen consumption ( J:66267 )

• mice have much higher rates of oxygen consumption compared to controls