Phenotypes Associated with This Genotype

Genotype
MGI:3839782

• Allelic Composition: Hfe^tm1.1Gfn/Hfe^tm1.1Gfn
• Genetic Background: B6.129P2-Hfe^tm1.1Gfn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body length ( J:114351 )

• mice have a decreased body length with a mean of 9.16 cm compared to 9.37 cm

limbs/digits/tail

short tail ( J:114351 )

• mean tail length is 7.92 cm versus 8.27

behavior/neurological

abnormal pilomotor reflex ( J:114351 )

• mice demonstrate more piloerection when being handled

abnormal postural reflex ( J:114351 )

• mice show greater splaying of the forelimbs as reflected in 37% greater distance between forelimbs when landing from a drop of 15 cm

impaired coordination ( J:114351 )

• mice have a decreased time of latency (74 seconds) on a rotating rod compared to controls (105 seconds)

abnormal gait ( J:114351 )

• there is an increased incidence of mice with abnormal hindlimb gaits

induced hyperactivity ( J:114351 )

• mice are hyperactive to tactile and auditory stimuli, or when handled

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hemochromatosis type 1		DOID:0111029	OMIM:235200	J:114351