Phenotypes Associated with This Genotype

Genotype
MGI:3839791

• Allelic Composition: Men1^tm1Gfk/Men1^tm1Gfk; Tg(Ins2-cre)25Mgn/0
• Genetic Background: involves: 129T2/SvEms * C57BL/6 * C57BL/6J * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased prolactinoma incidence ( J:89898 )

• by 12 months of age, 15 mice develop adenomas in the anterior pituitary gland that are prolactin positive

increased pancreas tumor incidence ( J:89898 )

• 7 of 21 mice develop pancreatic islet tumors that are positive for insulin

• islet tumors develop earlier and are more severe than those observed in Men1 knock-out heterozygotes

increased insulinoma incidence ( J:89898 )

endocrine/exocrine glands

pancreatic islet hyperplasia ( J:89898 )

• prominent in multiple islets consisting of beta cell hyperplasia

increased prolactinoma incidence ( J:89898 )

• by 12 months of age, 15 mice develop adenomas in the anterior pituitary gland that are prolactin positive

increased pancreas tumor incidence ( J:89898 )

• 7 of 21 mice develop pancreatic islet tumors that are positive for insulin

• islet tumors develop earlier and are more severe than those observed in Men1 knock-out heterozygotes

increased insulinoma incidence ( J:89898 )

nervous system

increased prolactinoma incidence ( J:89898 )

• by 12 months of age, 15 mice develop adenomas in the anterior pituitary gland that are prolactin positive

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple endocrine neoplasia type 1		DOID:10017	OMIM:131100	J:89898