Phenotypes Associated with This Genotype

Genotype
MGI:3840234

• Allelic Composition: Kdm3a^tm1.1Yzha/Kdm3a^tm1.1Yzha
• Genetic Background: B6.129P2-Kdm3a^tm1.1Yzha

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal spermatogenesis ( J:147295 )

♂

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:147295 )

N • despite obesity, leptin, noreponephrin, epinephrin, testosterone, adiponectin, T3, and corticosterone serum levels are normal

increased susceptibility to diet-induced obesity ( J:147295 )

impaired adaptive thermogenesis ( J:147295 )

• mice exhibit defective adaptive thermogenesis compared to wild-type mice

increased circulating cholesterol level ( J:147295 )

increased circulating free fatty acids level ( J:147295 )

increased circulating triglyceride level ( J:147295 )

hyperlipidemia ( J:147295 )

decreased oxygen consumption ( J:147295 )

• at night

adipose tissue

abnormal brown adipose tissue morphology ( J:147295 )

• brown adipose tissue exhibits increased fat content compared to in wild-type mice

increased brown adipose tissue amount ( J:147295 )

increased white fat cell lipid droplet size ( J:147295 )

increased percent body fat/body weight ( J:147295 )

• mice exhibit increased body fat compared to wild-type mice

abnormal brown adipose tissue physiology ( J:147295 )

• beta-adrenergic-stimulated oxygen consumption and glycerol release in brown adipose tissue is reduced compared to in wild-type mice

growth/size/body

obese ( J:147295 )

increased susceptibility to diet-induced obesity ( J:147295 )

liver/biliary system

hepatic steatosis ( J:147295 )

muscle

abnormal muscle morphology ( J:147295 )

• large fat droplets are observed in muscles unlike in wild-type mice

abnormal muscle physiology ( J:147295 )

• beta-oxidization in primary muscle is decreased compared to in wild-type mice

• glycerol release from the soleus muscle is decreased compared to in wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:147295 )

N • despite obesity, mice exhibit normal food intake regardless of diet fat content

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:147295