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Phenotypes Associated with This Genotype
Genotype
MGI:3840657
Allelic
Composition
Scn8a8J/Scn8a+
Genetic
Background
involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn8a8J mutation (2 available); any Scn8a mutation (99 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit robust spike wave discharge (SWD) with high amplitude, significant duration, high frequency, and a burst frequency of 7 to 9 Hz
• SWD occurs between periods of locomotor activity and cause immobility except for occasional whisker twitching
• the average incidence of SWD is higher Scn8amed heterozygotes
• ethosuximide treatment results in 6-fold fewer and shorter SWD
• the number of SWD per hour decreases with additional crosses to C57BL/6 mice
• mice exhibit fewer SWD compared to homozygous mice

nervous system
• the number of SWD per hour decreases with additional crosses to C57BL/6 mice
• ethosuximide treatment results in 6-fold fewer and shorter SWD
• mice exhibit robust spike wave discharge (SWD) with high amplitude, significant duration, high frequency, and a burst frequency of 7 to 9 Hz
• SWD occurs between periods of locomotor activity and cause immobility except for occasional whisker twitching
• the average incidence of SWD is higher Scn8amed heterozygotes
• mice exhibit fewer SWD compared to homozygous mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
epilepsy DOID:1826 J:147199 , J:212131


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory