Phenotypes Associated with This Genotype

Genotype
MGI:3841005

• Allelic Composition: Ccr2^tm1Mae/Ccr2^tm1Mae
• Genetic Background: B6.129P2-Ccr2^tm1Mae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

bronchiolitis ( J:162707 )

• mice infected with a recombinant mouse-adapted SARS-CoV, rMA15, develop more severe denuding bronchiolitis than similarly infected wild-type mice

vision/eye

retina photoreceptor degeneration ( J:147328 )

• at 16 months

abnormal retina pigment epithelium morphology ( J:147328 )

• after 9 months of age, lipofuscin granules are observed in the swollen and vacuolated retinal pigmented epithelial cells unlike in wild-type mice

• at 16 months, mice exhibit attenuation of the retinal pigmented epithelium unlike in wild-type mice

retina outer nuclear layer degeneration ( J:147328 )

• at 16 months

increased susceptibility to age-related retinal degeneration ( J:147328 )

• at 16 months, mice exhibit progressive outer retinal degeneration and confluent areas of visible atrophy unlike in wild-type mice

• at 18 months, mice exhibit geographic atrophy unlike in wild-type mice

retina deposits ( J:147328 )

• after 9 months of age, mice exhibit subretinal deposits similar to drusen that increase with age unlike in wild-type mice

abnormal optic choroid morphology ( J:147328 )

• age-dependent accumulation of macrophages in the choroids is less than in wild-type mice

abnormal choriocapillaris morphology ( J:147328 )

• at 16 months, mice exhibit dilation and attenuation of the choriocapillaris unlike wild-type mice

choroidal neovascularization ( J:147328 )

• at 15 to 19 months, mice exhibit intrachoroidal neovascularization with angiographic leakage unlike wild-type mice

• after 18 months, 3 of 13 mice exhibit choroidal neovascularization with angiographic leakage unlike in wild-type mice

• between 18 and 27 months, neovasculatization breaches the Bruch membrane and causes retinal pigmented epithelium and photoreceptor disruptions unlike in wild-type mice

abnormal Bruch membrane morphology ( J:147328 )

• the Bruch membrane is thickened compared to in wild-type mice after 9 months of age

• at 20 months, the outer Bruch membrane is breached by choriocapillary processes unlike in wild-type mice

behavior/neurological

alcohol aversion ( J:102583 )

• mice exhibit decreased preference for ethanol water compared with wild-type mice

• female mice exhibit a lesser ethanol preference compared with Ccl2^tm1Rol Ccr2^tm1Mae double homozygotes

decreased alcohol consumption ( J:102583 )

abnormal conditioned taste aversion behavior ( J:102583 )

• mice develop a stronger ethanol-induced conditioned taste aversion compared with similarly treated wild-type mice

increased fluid intake ( J:102583 )

• mice exhibit increased drinking of a quinine solution compared with wild-type mice

increased alcohol consumption ( J:102583 )

♂ • mice exhibit increased drinking of an ethanol solution compared with wild-type mice and Ccl2^tm1Rol Ccr2^tm1Mae double homozygotes

immune system

decreased macrophage cell number ( J:147328 )

• age-dependent accumulation of macrophages in the choroids is less than in wild-type mice

increased IgG level ( J:147328 )

• at 16 months, IgG is present in the retinal pigmented epithelium or choroids unlike in wild-type mice

• IgG light chain deposition in the retinal pigmented epithelium accumulates with age unlike in wild-type mice

bronchiolitis ( J:162707 )

• mice infected with a recombinant mouse-adapted SARS-CoV, rMA15, develop more severe denuding bronchiolitis than similarly infected wild-type mice

increased susceptibility to Coronaviridae infection ( J:162707 )

• mice show increased susceptibility to infection with a recombinant mouse-adapted SARS-CoV, rMA15 , developing more severe and prolonged disease compared to wild-type mice, showing more prominent airway epithelial cell apoptosis, severe denuding bronchiolitis and perivenular/periarterial cuffing

cardiovascular system

abnormal choriocapillaris morphology ( J:147328 )

• at 16 months, mice exhibit dilation and attenuation of the choriocapillaris unlike wild-type mice

choroidal neovascularization ( J:147328 )

• at 15 to 19 months, mice exhibit intrachoroidal neovascularization with angiographic leakage unlike wild-type mice

• after 18 months, 3 of 13 mice exhibit choroidal neovascularization with angiographic leakage unlike in wild-type mice

• between 18 and 27 months, neovasculatization breaches the Bruch membrane and causes retinal pigmented epithelium and photoreceptor disruptions unlike in wild-type mice

nervous system

retina photoreceptor degeneration ( J:147328 )

• at 16 months

pigmentation

abnormal retina pigment epithelium morphology ( J:147328 )

• after 9 months of age, lipofuscin granules are observed in the swollen and vacuolated retinal pigmented epithelial cells unlike in wild-type mice

• at 16 months, mice exhibit attenuation of the retinal pigmented epithelium unlike in wild-type mice

lipofuscinosis ( J:147328 )

• after 9 months of age, lipofuscin granules are observed in the swollen and vacuolated retinal pigmented epithelial cells unlike in wild-type mice

hematopoietic system

decreased macrophage cell number ( J:147328 )

• age-dependent accumulation of macrophages in the choroids is less than in wild-type mice

increased IgG level ( J:147328 )

• at 16 months, IgG is present in the retinal pigmented epithelium or choroids unlike in wild-type mice

• IgG light chain deposition in the retinal pigmented epithelium accumulates with age unlike in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
age related macular degeneration		DOID:10871	OMIM:PS603075	J:147328
Coronavirus infectious disease		DOID:0080599		J:162707