Phenotypes Associated with This Genotype

Genotype
MGI:3841558

• Allelic Composition: Tacr3^tm1Jasi/Tacr3^tm1Jasi
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:182547 , J:223528 )

N • male mice exhibit normal penile width and timing of preputial separation at P20 and timing of preputial separation at P60 (J:182547)

N • male mice exhibit all stages of spermatogenesis, normal serum levels of testosterone and LH, and are fertile (J:182547)

N • female mice exhibit normal average day of first estrus, ovarian weights, follicle maturation, ovulation, induced superovulation and levels of gonadotrophin, FSH and LH (J:182547)

♀N • female mice exhibit normal timing of vaginal opening and first estrous (J:223528)

small testis ( J:182547 )

♂ • at P60

♂ • however, gross architecture is normal

decreased uterus weight ( J:182547 )

♀

abnormal estrous cycle ( J:182547 )

♀ • mice are acyclic or have irregular cycles

prolonged diestrus ( J:182547 )

♀ • in some mice

reduced female fertility ( J:182547 )

♀ • female mice are sub-fertile, failing to sustain reproductive robustness

♀ • however, the average latency to first litter is normal

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:182547 )

N • mice exhibit normal numbers of gonadotropin-releasing hormone neurons

small testis ( J:182547 )

♂ • at P60

♂ • however, gross architecture is normal

behavior/neurological

abnormal active avoidance behavior ( J:147538 )

• mice require a greater number of training sessions and never reach the same level of proficiency as the wild-type mice in actively avoiding a shock by crossing into a non-shock chamber

impaired passive avoidance behavior ( J:147538 )

• mice exhibit decreased latency in entering a darkened chamber they had previously been shocked in 48-72 hours earlier

abnormal spatial learning ( J:147538 )

• on the third day of testing in a Morris water maze, mice take significantly longer than controls to find the hidden platform

homeostasis/metabolism

decreased circulating follicle stimulating hormone level ( J:182547 )

♂ • in male mice

growth/size/body

decreased body weight ( J:182547 )

♀ • on P60 in female, but not male, mice

♀ • however, at other time points mice exhibit normal body weight

increased body weight ( J:147538 )

• mice weigh 7-10% more than controls; gain in weight over controls increases with age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypogonadotropic hypogonadism 11 with or without anosmia		DOID:0090071	OMIM:614840	J:182547