Phenotypes for Prkcd MGI:3841648 MGI Mouse

• perivascular infiltration of leukocytes, comprised mostly of B cells, is observed in the kidney, liver, lungs, and salivary glands unlike in wild-type mice

glomerulonephritis ( J:76135 )

• glomeruli are enlarged and stain positive for IgG and C3 in the mesangial region and along capillary walls unlike in wild-type mice

glomerulonephritis ( J:76135 )

• glomeruli are enlarged and stain positive for IgG and C3 in the mesangial region and along capillary walls unlike in wild-type mice

renal glomerular immunoglobulin deposits ( J:76135 )

abnormal pancreatic beta cell morphology ( J:120293 )

• the total number of insulin granules is greater than in wild-type beta-cells

• following glucose treatment, the number of granules within 100 nm or 100-200 nm from the plasma membrane is increased compared to in wild-type beta-cells

decreased insulin secretion ( J:120293 )

• mice exhibit reduced glucose-stimulated insulin secretion compared to in wild-type mice

• islet cells stimulated with glucose-, KCl-, or phorbol 12-myristate 13-acetate with or without forskolin exhibit decreased insulin secretion compared to in wild-type cells

decreased body weight ( J:120293 )

• modestly

enlarged spleen ( J:76135 )

increased B cell proliferation ( J:76135 , J:143854 )

• in response to F(ab)s specific for IgM and antibodies to CD40 or LSP (J:76135)

• when transferred into Rag null mice, more B220+ IgM+ cells compared to when wild-type cells are transplanted (J:76135)

• when stimulated with anti-CD40 antibodies or anti-IgM antibodies (J:143854)

enlarged spleen ( J:76135 )

abnormal plasma cell differentiation ( J:143854 )

• anti-CD40- and IL4-stimulated splenic B cells exhibit enhanced differentiation into IgG producing plasma cells compared to in wild-type mice

increased B cell number ( J:76135 )

• the number of IgM+ TCR(beta)- B220+ cells are increased in the spleen and lymph nodes compared to in wild-type mice

• however, the numbers of splenic and peritoneal CD5+ B lymphocytes are normal

• when transferred into Rag null mice, more B220+ IgM+ cells compared to when wild-type cells are transplanted

increased transitional stage B cell number ( J:143854 )

• T1 and T2 B cells are increased 2- to 3-fold compared to in wild-type mice

increased follicular B cell number ( J:143854 )

• 2- to 3-fold

increased marginal zone B cell number ( J:143854 )

• 2- to 3-fold

increased spleen germinal center number ( J:76135 )

abnormal immunoglobulin level ( J:143854 )

increased IgA level ( J:76135 , J:143854 )

increased IgG1 level ( J:76135 , J:143854 )

increased IgM level ( J:143854 )