Phenotypes Associated with This Genotype

Genotype
MGI:3841692

• Allelic Composition: Tg(Igh-V186.2-TCL1A)3Cro/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

peritoneal inflammation ( J:76574 )

• cellularity in the peritoneal cavity is increased 50- to 100- fold compared to controls due to presence of large B1b B-cell population

spleen hyperplasia ( J:76574 )

• spleens are enlarged 1.5-fold compared to controls in mice under 1 year of age

• spleen weight increases to 20-fold or higher than controls after the onset of leukemia

abnormal B cell morphology ( J:76574 )

• an abnormal CD5⁺ CD11b⁺ population is found in all transgenic mice

• this B cell population makes up 44% of cells in the peritoneal cavity of 2-month old mice, 8.6% of splenocytes by 4 months of age, 43% of bone marrow cells by 8 months of age

increased marginal zone B cell number ( J:76574 )

• increased numbers of B cells are found in the marginal zone with a CD21^loCD5⁺ phenotype

neoplasm

increased leukemia incidence ( J:76574 )

• clonality of cells is observed in the CD5⁺ B cell population in mice over 7 months of age

• these cells have low proliferative activity, which is a characteristic of leukemia cells

• mice 13-18 months of age become visibly ill, have enlarged liver, spleens, and lymph nodes, and have white blood cell counts that are 50-fold higher than normal

• blood of these older mice contain large lymphoid cells, smeared cells, and lymphocytes with clumped nuclear chromatin

digestive/alimentary system

peritoneal inflammation ( J:76574 )

• cellularity in the peritoneal cavity is increased 50- to 100- fold compared to controls due to presence of large B1b B-cell population

liver/biliary system

enlarged liver ( J:76574 )

• livers are enlarged after the onset of leukemia

hematopoietic system

spleen hyperplasia ( J:76574 )

• spleens are enlarged 1.5-fold compared to controls in mice under 1 year of age

• spleen weight increases to 20-fold or higher than controls after the onset of leukemia

abnormal B cell morphology ( J:76574 )

• an abnormal CD5⁺ CD11b⁺ population is found in all transgenic mice

• this B cell population makes up 44% of cells in the peritoneal cavity of 2-month old mice, 8.6% of splenocytes by 4 months of age, 43% of bone marrow cells by 8 months of age

increased marginal zone B cell number ( J:76574 )

• increased numbers of B cells are found in the marginal zone with a CD21^loCD5⁺ phenotype

growth/size/body

enlarged liver ( J:76574 )

• livers are enlarged after the onset of leukemia

spleen hyperplasia ( J:76574 )

• spleens are enlarged 1.5-fold compared to controls in mice under 1 year of age

• spleen weight increases to 20-fold or higher than controls after the onset of leukemia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:76574