Phenotypes Associated with This Genotype

Genotype
MGI:3841693

cx3

• Allelic Composition: Blnk^tm1Dkit/Blnk^tm1Dkit; Prkcd^tm1Kin/Prkcd^tm1Kin
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell apoptosis ( J:143854 )

abnormal B cell proliferation ( J:143854 )

• mice exhibit poor response to anti-IgM antibodies or LPS but a stronger than normal response to anti-CD40 antibodies

abnormal plasma cell differentiation ( J:143854 )

• anti-CD40- and IL4-stimulated splenic B cells exhibit moderately enhanced differentiation into IgG producing plasma cells compared to in wild-type mice

arrested B cell differentiation ( J:143854 )

• as in Blnk^tm1Dkit homozygotes

decreased B-1 B cell number ( J:143854 )

• in the peritoneal cavity

decreased B-2 B cell number ( J:143854 )

• in the peritoneal cavity

decreased follicular B cell number ( J:143854 )

decreased marginal zone B cell number ( J:143854 )

abnormal immunoglobulin level ( J:143854 )

increased IgA level ( J:143854 )

• higher than in Blnk^tm1Dkit homozygotes

increased IgG1 level ( J:143854 )

• higher than in Blnk^tm1Dkit homozygotes

increased IgG2b level ( J:143854 )

• higher than in Blnk^tm1Dkit homozygotes

increased IgG3 level ( J:143854 )

• 10-fold higher than in Blnk^tm1Dkit homozygotes

increased IgM level ( J:143854 )

• 10-fold higher than in Blnk^tm1Dkit homozygotes

hematopoietic system

increased B cell apoptosis ( J:143854 )

abnormal B cell proliferation ( J:143854 )

• mice exhibit poor response to anti-IgM antibodies or LPS but a stronger than normal response to anti-CD40 antibodies

abnormal plasma cell differentiation ( J:143854 )

• anti-CD40- and IL4-stimulated splenic B cells exhibit moderately enhanced differentiation into IgG producing plasma cells compared to in wild-type mice

arrested B cell differentiation ( J:143854 )

• as in Blnk^tm1Dkit homozygotes

decreased B-1 B cell number ( J:143854 )

• in the peritoneal cavity

decreased B-2 B cell number ( J:143854 )

• in the peritoneal cavity

decreased follicular B cell number ( J:143854 )

decreased marginal zone B cell number ( J:143854 )

abnormal immunoglobulin level ( J:143854 )

increased IgA level ( J:143854 )

• higher than in Blnk^tm1Dkit homozygotes

increased IgG1 level ( J:143854 )

• higher than in Blnk^tm1Dkit homozygotes

increased IgG2b level ( J:143854 )

• higher than in Blnk^tm1Dkit homozygotes

increased IgG3 level ( J:143854 )

• 10-fold higher than in Blnk^tm1Dkit homozygotes

increased IgM level ( J:143854 )

• 10-fold higher than in Blnk^tm1Dkit homozygotes

cellular

increased B cell apoptosis ( J:143854 )

abnormal B cell proliferation ( J:143854 )

• mice exhibit poor response to anti-IgM antibodies or LPS but a stronger than normal response to anti-CD40 antibodies