Phenotypes Associated with This Genotype

Genotype
MGI:3841727

hm1

• Allelic Composition: Prkcd^tm1Kin/Prkcd^tm1Kin
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal osteoblast differentiation ( J:117333 )

• as determined by marker expression, osteoblast differentiation is impeded compared to in wild-type mice

• at E13.5, cultured limb priomordial cells produce fewer bone nodules and more cartilage nodules than formed by wild-type cells

decreased width of hypertrophic chondrocyte zone ( J:117333 )

abnormal bone ossification ( J:117333 )

• at E15.5, mice exhibit less ossification compared to wild-type mice

• at E15.5, mineralization of the maxilla and mandible is minimal compared to in wild-type mice

• at E14.5 and E15.5, bone collars of ossifying skeletal elements, specifically long bones, are shorter than in wild-type mice

cellular

abnormal osteoblast differentiation ( J:117333 )

• as determined by marker expression, osteoblast differentiation is impeded compared to in wild-type mice

• at E13.5, cultured limb priomordial cells produce fewer bone nodules and more cartilage nodules than formed by wild-type cells